Search
Search Results
-
The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells
BackgroundFormyl peptide receptor 2 (Fpr2) plays a crucial role in colon homeostasis and microbiota balance. Commensal E. coli is known to promote...
-
Polymorphism of formyl peptide receptor 1 (FPR1) reduces the therapeutic efficiency and antitumor immunity after neoadjuvant chemoradiotherapy (CCRT) treatment in locally advanced rectal cancer
Immunosurveillance and immunoscavenging prompted by preoperative chemoradiotherapy (CCRT) may contribute to improve local control and increase...
-
Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis
Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on...
-
FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition
ObjectivePremature rupture of membranes (PROM) is a common pregnancy disorder that is closely associated with structural weakening of fetal...
-
From odor to oncology: non-canonical odorant receptors in cancer
Odorant receptors, traditionally associated with olfaction as chemoreceptors, have been increasingly recognized for their presence and diverse...
-
Neutrophil activation in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis and large-vessel vasculitis
ObjectiveTo assess markers of neutrophil activation such as calprotectin and N-formyl methionine (fMET) in anti-neutrophil cytoplasmic...
-
Role of Soluble Urokinase-Type Plasminogen Activator Receptor in Cardiovascular Disease
Purpose of ReviewChronic inflammation is a major contributor to cardiovascular disease (CVD) risk. Soluble urokinase plasminogen activator receptor...
-
Detection of Osteoarthritis Inflammation by Single-Photon Emission Computed Tomography Based on an Inflammation-Targeting Peptide cFLFLF
PurposeAlthough inflammation has been recognized as a key process in the pathogenesis of osteoarthritis (OA), there remains no clinical noninvasive...
-
Combined Application of Exosomes and FPR2 Agonist LXA4 in Controlling Fetal Membrane Inflammation and Promoting Fetal Membrane Tissue Repair
Preterm premature rupture of membranes (pPROM) is a common pregnancy disease closely related to inflammation. The formyl peptide receptor 2 (FPR2), a...
-
The time-dependent expression of FPR2 and ANXA1 in murine deep vein thrombosis model and its relation to thrombus age
Thrombus age determination in fatal venous thromboembolism cases is an important task for forensic pathologists. In this study, we investigated the...
-
The effect of the WKYMVm peptide on promoting mBMSC secretion of exosomes to induce M2 macrophage polarization through the FPR2 pathway
BackgroundWhen multicystic vesicles (precursors of exosomes) are formed in cells, there are two results. One is decomposition by lysosomes, and the...
-
Low Annexin A1 level in HTLV-1 infected patients is a potential biomarker for the clinical progression and diagnosis of HAM/TSP
BackgroundHuman T-lymphotropic virus 1 (HTLV-1) is etiologically associated with the chronic inflammatory neurodegenerative disease HTLV-1-associated...
-
Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review
Purpose of the ReviewSystemic sclerosis (SSc) is a condition of dermal and visceral scar formation characterized by immune dysregulation and...
-
Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity
BackgroundA dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate...
-
FPR2 participates in epithelial ovarian cancer (EOC) progression through RhoA-mediated M2 macrophage polarization
BackgroundIn our previous study, we found that formyl peptide receptor 2 (FPR2) promoted the invasion and metastasis of epithelial ovarian cancer...
-
Suppression of FPR2 expression inhibits inflammation in preeclampsia by improving the biological functions of trophoblast via NF-κB pathway
PurposeThe dysfunction of trophoblast during inflammation plays an important role in PE. Formyl peptide receptor 2 (FPR2) plays crucial roles in the...
-
Annexin A1 and its receptor gene polymorphisms in systemic lupus erythematosus in the Tunisian population
BackgroundAn association between ANXA1 , FPR1 and FPR2 gene polymorphisms and the patho-physiology of many human diseases was suggested by numerous...
-
Targeting immune cell recruitment in atherosclerosis
Atherosclerosis is the primary underlying cause of myocardial infarction and stroke. Atherosclerotic cardiovascular disease is characterized by a...
-
The absence of murine cathelicidin-related antimicrobial peptide impacts host responses enhancing Salmonella enterica serovar Typhimurium infection
BackgroundCathelicidins are a class of antimicrobial peptide, and the murine cathelicidin-related antimicrobial peptide (mCRAMP) has been...
