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Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice
BackgroundGout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class...
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Comparison of the different monosodium urate crystals in the preparation process and pro-inflammation
ObjectivesThe deposition of monosodium urate (MSU) crystals within synovial joints and tissues is the initiating factor for gout arthritis. Thus, MSU...
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Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium
ObjectivesMethotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA...
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[68Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation
BackgroundImaging diagnosis of inflammation has been challenging for many years. Inflammation imaging agents commonly used in nuclear medicine, such...
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Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss
Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL) during chronic inflammatory diseases. However, the specific...
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Use of coffee husks – comparison of pellet bedding quality, performance features, and some welfare indicators of broiler chickens
BackgroundThe study aimed to evaluate the influence of wheat straw and different coffee husk (CHs) levels in pellet bedding on its quality, broiler...
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Correlation between footpad lesions and systemic bacterial infections in broiler breeders
Footpad lesions are an important factor in evaluation of animal welfare in broilers regulated by law; however, no legal requirements have been set...
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CD45− erythroid progenitor cells promote lymph node metastasis in gastric cancer by inducing a hybrid epithelial/mesenchymal state in lymphatic endothelial cells
Background and aimsSpecific mechanisms of lymph node (LN) metastasis in early-stage gastric cancer (GC) have not been elucidated. The role of anemia,...
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Spontaneous autoimmune subepidermal blistering diseases in animals: a comprehensive review
Autoimmune subepidermal blistering diseases (AISBDs) are rare skin disorders of animals that were first identified in dogs but several AISBDs are now...
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Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice
ObjectiveGout is characterized by inflammatory arthritis with hyperuricaemia and deposition of monosodium urate (MSU) crystals in the joints. Several...
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Comparison of hock- and footpad-injection as a prostate adenocarcinoma model in rats
BackgroundObjective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor...
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Screening assessment of trimethoxy flavonoid and - (-)-epigallocatechin-3-gallate against formalin-induced arthritis in Swiss albino rats and binding properties on NF-κB-MMP9 proteins
BackgroundThe isolated trimethoxy flavonoid 4a,5,8,8a-tetrahydro-5-hydroxy-3,7,8-trimethoxy-2-(3,4-dimethoxyphenyl) chromen-4-one (TMF) from...
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Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
BackgroundGouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate...
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Melittin as a safe compound to BALB/c mice immune system; a tiered approach immunotoxicity screening
BackgroundMaintenance of immune system integrity is a vital requirement to protect human body against pathogens/cancers. Natural compounds have long...
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N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice
BackgroundLeishmaniasis is a emergent disease characterized by different clinical manifestations in both humans and dogs. Predominant clinical...
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Macrophage mannose receptor CD206 targeting of fluoride-18 labeled mannosylated dextran: A validation study in mice
PurposeAluminum fluoride-18-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated mannosylated dextran derivative (Al[ 18 F]F-NOTA-D10CM) is...
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Immunomodulation of Macrophages May Benefit Cutaneous Leishmaniasis Outcome
Purpose of ReviewThis review emerges from the necessity to gather information of quality on the possibility to directly modulate macrophages and its...
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Recent Advances in Management of Neuropathic, Nociceptive, and Chronic Pain: A Narrative Review with Focus on Nanomedicine, Gene Therapy, Stem Cell Therapy, and Newer Therapeutic Options
Purpose of ReviewThis manuscript summarizes novel clinical and interventional approaches in the management of chronic, nociceptive, and neuropathic...
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Naringenin and cryptotanshinone shift the immune response towards Th1 and modulate T regulatory cells via JAK2/STAT3 pathway in breast cancer
BackgroundUse of natural products has been proposed as an efficient method in modulation of immune system and treatment of cancers. The aim of this...
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Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study
BackgroundWith the emergence of many side effects from synthetic drugs, there is an urgent need to find a natural alternative to these products....
