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Myocardial perfusion imaging with retrospective gating and integrated correction of attenuation, scatter, respiration, motion, and arrhythmia
BackgroundAbsolute quantitative myocardial perfusion SPECT requires addressing of aleatory and epistemic uncertainties in conjunction with providing...
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Effect of kilovoltage and quality reference mAs on CT-based attenuation correction in 177Lu SPECT/CT imaging: a phantom study
IntroductionCT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect...
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Feasibility of ultra-high-speed acquisition in xSPECT bone algorithm: a phantom study with advanced bone SPECT-specific phantom
ObjectiveAlthough xSPECT Bone (xB) provides quantitative single-photon emission computed tomography (SPECT) high-resolution images, patients’ burden...
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Position dependence of recovery coefficients in 177Lu-SPECT/CT reconstructions – phantom simulations and measurements
BackgroundAlthough the importance of quantitative SPECT has increased tremendously due to newly developed therapeutic radiopharmaceuticals, there are...
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Impact of metal implants on xSPECT/CT Bone reconstruction: the “shining metal artefact”
BackgroundNovel reconstruction algorithms, such as xSPECT Bone, are gaining more and more importance in Nuclear Medicine. With xSPECT Bone, the...
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Single-site 123I-FP-CIT reference values from individuals with non-degenerative parkinsonism—comparison with values from healthy volunteers
PurposeIodine 123-radiolabeled 2β-carbomethoxy-3β-(4-iodophenyl)- N -(3-fluoropropyl) nortropane ( 123 I-FP-CIT) SPECT can be performed to distinguish...
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CMR validation of left ventricular volumes and ejection fraction measured by the IQ-SPECT system in patients with small heart size
BackgroundThe IQ-SPECT system is equipped with multifocal collimators and uses ordered-subset conjugate gradient minimization (OSCGM) as its...
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Semi-quantitative analysis of visually normal 123I-FP-CIT across three large databases revealed no difference between control and patients
BackgroundTo show the equivalence between the specific binding ratios (SBR) of visually normal 123 I-FP-CIT SPECT scans from patients to those from...
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The effect of long-acting somatostatin analogues on the uptake of [177Lu]Lu-HA-DOTATATE
PurposeAccording to IAEA/EANM/SNMMI guidelines, long-acting somatostatin analogues (LA-SSAs) should be discontinued 4–6 weeks prior to peptide...
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First validation of stress myocardial perfusion scintigraphy using a novel reconstruction process
BackgroundA new image reconstruction process termed the MUS method (masking process on unsmoothed images) was developed to eliminate artifacts,...
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Accuracy of dynamic sentinel lymph node biopsy for inguinal lymph node staging in cN0 penile cancer
BackgroundPenile cancer is characterized by an early lymphatic dissemination. In intermediate and high-risk primary tumors without palpable inguinal...
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Clinical validation of an AI-based automatic quantification tool for lung lobes in SPECT/CT
BackgroundLung lobar ventilation and perfusion (V/Q) quantification is generally obtained by generating planar scintigraphy images and then imposing...
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The potential of the Crystal Cam handheld gamma-camera for preoperative and intraoperative sentinel lymph node localization in early-stage oral cancer
PurposeEvaluating the Crystal Cam handheld gamma-camera for preoperative and intraoperative sentinel lymph node (SLN) localization in early-stage...
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Accuracy comparison of various quantitative [99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses
BackgroundThere is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of...
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Post-PRRT scans: which scans to make and what to look for
AimThe aim of this study was to evaluate the clinical utility of SPECT/CT (imaging of uptake in tumor lesions and additional findings) and the...
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Diagnostic performance of quantitative Ga-SPECT/CT for patients with lower-limb osteomyelitis
BackgroundPatients with lower-limb osteomyelitis (LLOM) may experience major adverse events, such as lower-leg amputations or death; therefore, early...
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“Virtual” attenuation correction: improving stress myocardial perfusion SPECT imaging using deep learning
PurposeMyocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) is widely used for coronary artery disease (CAD)...
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Anti-GD2 antibody for radiopharmaceutical imaging of osteosarcoma
PurposeOsteosarcoma (OS) is the most frequently diagnosed bone cancer in children with little improvement in overall survival in the past decades....
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Tumor dosimetry using 177Lu: influence of background activity, measurement method and reconstruction algorithm
BackgroundImage-based tumor dosimetry after radionuclide therapy, using the isotope 177 Lu, finds application e.g., for tumor-to-organ dose...
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Quantification evaluation of 99mTc-MDP concentration in the lumbar spine with SPECT/CT: compare with bone mineral density
BackgroundDespite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has...
