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EANM guidance document: dosimetry for first-in-human studies and early phase clinical trials
The numbers of diagnostic and therapeutic nuclear medicine agents under investigation are rapidly increasing. Both novel emitters and novel carrier...
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Clinical issues facing pouch patients: an introduction to a special issue on the ileal pouch
For over 40 years, restorative proctocolectomy has been used in patients with ulcerative colitis or familial adenomatous polyposis undergoing...
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A database for oncological research and quality assurance: implementation and first experiences with the University Clinical Cancer Registry Regensburg
Legal requirements, certification specifications, as well as the demand for real world data on cancer research and treatment led to the decision to...
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Predicting and modifying success on the NBME surgery subject exam
PurposeThe National Board of Medical Examiners (NBME) surgery subject exam (SSE) is a high-stakes exam with few predictors of success. We...
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Special FDA designations for drug development: orphan, fast track, accelerated approval, priority review, and breakthrough therapy
BackgroundOver the past decades, US Congress enabled the US Food and Drug Administration (FDA) to facilitate and expedite drug development for...
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Patch Testing in Special Populations: a Review
Contact dermatitis is a frequent and highly impacting skin disorder. Patch testing remains the standard procedure for the diagnosis of allergic...
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Physiologically Based Pharmacokinetic (PBPK) Model-Informed Dosing Guidelines for Pediatric Clinical Care: A Pragmatic Approach for a Special Population
Physiologically based pharmacokinetic (PBPK) modeling can be an attractive tool to increase the evidence base of pediatric drug dosing...
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Swimming-induced changes in pulmonary function: special observations for clinical testing
BackgroundA special improvement in pulmonary function is found in swimmers. In clinical testing the airway reactivity is observed at certain exercise...
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Official Position of the Brazilian Association of Bone Assessment and Metabolism (ABRASSO) on the evaluation of body composition by densitometry—part II (clinical aspects): interpretation, reporting, and special situations
ObjectiveTo present an updated and evidence-based guideline for the use of dual-energy x-ray absorptiometry (DXA) to assess body composition in...
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Redefining Disease Severity with Special Area Involvement and Reflecting on Treatment Patterns in a Real-World Psoriasis Population
BackgroundThe International Psoriasis Council (IPC) recommends an approach that considers body surface area (BSA), involvement in special areas, and...
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The future of clinical trials—goals, ideas, and discussion
Clinical trials are subject to an ever-evolving landscape of treatment options, regulatory requirements, socioeconomic conditions, and paradigms of...
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A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer’s Disease
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct...
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Reflections on appropriately liberalizing ART for groups requiring special attention in China
PurposeThe continuous advancement of assisted reproductive technologies (ART) and the evolving attitudes towards marriage and fertility among the...
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Development of core outcome sets of Food for Special Medical Purposes designed for type 2 diabetes mellitus: a study protocol
BackgroundThe Chinese government stipulates all food for special medical purposes (FSMP) designed for specific diseases to be tested in clinical...
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Joint EANM-SNMMI guideline on the role of 2-[18F]FDG PET/CT in no special type breast cancer
IntroductionThere is much literature about the role of 2-[ 18 F]FDG PET/CT in patients with breast cancer (BC). However, there exists no international...
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Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design
BackgroundBased on the current state of research regarding the treatment in pediatric obsessive–compulsive disorder (OCD), cognitive behavioral...
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Cerebrospinal fluid abnormalities in first- and multi-episode schizophrenia-spectrum disorders: impact of clinical and demographical variables
Multiple lines of evidence indicate that immunological and inflammatory alterations contribute at least in a subgroup to the pathophysiology of...
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Individual 3D-printed fixation masks for radiotherapy: first clinical experiences
PurposeTo show the feasibility of 3D-printed fixation masks for whole brain radiation therapy in a clinical setting and perform a first comparison to...
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Clinical effectiveness of supraspinatus tendon reconstruction using autogenous fascia latas for irreparable posterosuperior massive rotator cuff tears: study protocol for a randomized, controlled clinical trial
BackgroundSupraspinatus tendon reconstruction (STR) was recently introduced as a new treatment option for irreparable posterosuperior massive rotator...
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A novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning
Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all aspects of personal functioning. While SCZ has a very...
