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Addressing comprehensive complexities a striking familial hypercholesterolemia case study
BackgroundPremature aortic involvement and comprehensive management strategies in familial hypercholesterolemia familial hypercholesterolemia (FH), a...
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Measuring Costs of Cardiovascular Disease Prevention for Patients with Familial Hypercholesterolemia in Administrative Claims Data
IntroductionFamilial hypercholesterolemia is a common genetic condition that significantly increases an individual’s risk of cardiovascular events...
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The Clinical Importance of Differentiating Monogenic Familial Hypercholesterolemia from Polygenic Hypercholesterolemia
Purpose of ReviewThe current review discusses the importance and significance of differentiating monogenic familial hypercholesterolemia (FH) from...
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Familial hypercholesterolemia care by Dutch pediatricians—mind the gaps
PurposeFamilial hypercholesterolemia (FH) leads to elevated low-density lipoprotein cholesterol levels, which increases the risk of premature...
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Early echocardiographic signs of cardiovascular affection in pediatric familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a rare autosomal dominant genetic disorder caused by defective low-density lipoprotein (LDL) receptors or...
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A mini-review of efficacy, safety, and influence of novel evinacumab on familial hypercholesterolemia
BackgroundFamilial hypercholesterolemia (FH) poses a substantial risk of cardiovascular diseases. The recent approval of evinacumab signifies a...
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Sex Differences in Familial Hypercholesterolemia
Purpose of ReviewThis review aims to summarize the existing research on sex differences in familial hypercholesterolemia (FH) across the lifespan.
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Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia?
Purpose of ReviewThis review discusses whether patients’ genotype affects the efficacy of PCSK9 inhibitors in treating familial hypercholesterolemia...
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Stratification in Heterozygous Familial Hypercholesterolemia: Imaging, Biomarkers, and Genetic Testing
Purpose of ReviewHeterozygous familial hypercholesterolemia (HeFH) is the most common monogenic autosomal dominant disorder. However, the condition...
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Peripheral artery disease: an underdiagnosed condition in familial hypercholesterolemia? A systematic review
PurposeFamilial hypercholesterolemia (FH) is one of the most common inherited diseases characterized by elevated LDL-cholesterol levels, leading to...
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Familial Hypercholesterolemia and Lipoprotein(a): Two Partners in Crime?
Purpose of ReviewFamilial hypercholesterolemia is a high cardiovascular risk disorder. We will review the role of lipoprotein(a) in cardiovascular...
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The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
Purpose of ReviewFamilial Hypercholesterolemia (FH) is a common genetic disorder characterized by lifelong elevation of severely elevated plasma...
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Detecting Familial hypercholesterolemia in children and adolescents: potential and challenges
BackgroundIt is now well established that atherosclerosis begins in childhood and evolves through adolescence and young adulthood, ultimately...
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Lipoprotein Apheresis: Current Recommendations for Treating Familial Hypercholesterolemia and Elevated Lipoprotein(a)
Purpose of ReviewFamilial hypercholesterolemia (FH) and hyperlipoproteinemia(a) are relatively common disorders, posing a significant health burden...
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Lipoprotein(a) as Part of the Diagnosis of Clinical Familial Hypercholesterolemia
Purpose of ReviewIndividuals with familial hypercholesterolemia have very high risk of cardiovascular disease due to lifelong elevations in LDL...
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Parental Attitudes and Ideas Regarding Newborn Screening for Familial Hypercholesterolemia
BackgroundFamilial hypercholesterolemia (FH) is an inherited disease which causes premature atherosclerotic cardiovascular disease. However, less...
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An update on lipid apheresis for familial hypercholesterolemia
Familial hypercholesterolemia (FH) is an inherited metabolic defect leading to increased total cholesterol and low-density cholesterol (LDL) from...
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Prevalence of familial hypercholesterolemia in patients with confirmed premature coronary artery disease in Ranchi, Jharkhand
BackgroundFamilial hypercholesterolemia (FH) is an under-diagnosed autosomal co-dominant genetic disorder characterized by very high plasma levels of...
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Different clinical phenotypes of a pair of siblings with familial hypercholesterolemia: a case report and literature review
BackgroundFamilial hypercholesterolemia (FH) leads to high plasma low-density lipoprotein cholesterol (LDL-C) levels and early cardiovascular...
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Genetic Testing for Familial Hypercholesterolemia in Clinical Practice
Purpose of ReviewGenetic testing has proven utility in identifying and diagnosing individuals with FH. Here we outline the current landscape of...