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1. EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA

   Background

   As a skeletal malignancy, osteosarcoma has high incidence among primary malignant bone tumors. With increasing researches on molecules...

   Ou Shuang, Jianmin Zhou, ... Meng Xu in Journal of Orthopaedic Surgery and Research

   Article Open access 27 June 2022
   

2. Diagnostic significance of serum FGD5-AS1 and its predictive value for the development of cardiovascular diseases in patients with type 2 diabetes

   Background

   As a result of the continuous rise in the incidence of type 2 diabetes mellitus (T2DM), related cardiovascular diseases (CVDs) have been a...

   Yongdi Wang, Jian Wang in Diabetology & Metabolic Syndrome

   Article Open access 28 January 2022
   

3. FGD5-AS1 facilitates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells via targeting the miR-506-3p/BMP7 axis

   Background

   Osteoporosis is a systemic disease characterized by impaired bone formation, increased bone resorption, and brittle bone fractures. The...

   Jun Li, **ngbiao Wu, ... Hong Zhao in Journal of Orthopaedic Surgery and Research

   Article Open access 12 November 2021
   

4. The role of miR-153 and related upstream/downstream pathways in cancers: from a potential biomarker to treatment of tumor resistance and a therapeutic target

   MicroRNAs (miRNAs/miRs) are small non-coding RNAs that have a multifunction and play essential roles in gene regulation. Their dysregulation is...

   Vahab Alamdari-Palangi, Khojaste Rahimi Jaberi, ... Amir Savardashtaki in Medical Oncology

   Article 28 April 2022
   

5. Unveiling the functional paradigm of exosome-derived long non-coding RNAs (lncRNAs) in cancer: based on a narrative review and systematic review

   Background and purpose

   The intricate mechanisms underlying intercellular communication within the tumor microenvironment remain largely elusive....

   Wenhan Wu, Jia He in Journal of Cancer Research and Clinical Oncology

   Article 14 August 2023
   

6. Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights

   Purpose of Review

   Abdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal aorta,...

   Haorui Zhang, Ke Zhang, ... Chenxi Ouyang in Current Atherosclerosis Reports

   Article 06 May 2024
   

7. Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis

   Background

   5-fluorouracil (5-FU) is conventionally used in chemotherapy for colon adenocarcinomas. Acquired resistance of 5-FU remains a clinical...

   Zhongshi Hong, Yachen Li, ... Chengzhi Qiu in Discover Oncology

   Article Open access 28 May 2024
   

8. Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study

   Aims/hypothesis

   The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with...

   Juliette A. de Klerk, Joline W. J. Beulens, ... Roderick C. Slieker in Diabetologia

   Article Open access 24 February 2023
   

9. Bioinformatics analysis of hedgehog interacting protein in colorectal cancer: a study based on GEO data and TCGA data

   Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Hedgehog Interacting Protein (HHIP) is evolutionarily conserved protein,...

   Fengyihuan Fu, Yuan Zhang, ... Yuqiang Nie in BMC Gastroenterology

   Article Open access 11 August 2023
   

10. Knockdown of Mmu-circ-0001380 Attenuates Myocardial Ischemia/Reperfusion Injury via Modulating miR-106b-5p/Phlpp2 Axis

    Myocardial ischemia/reperfusion (MI/R) injury induces myocardial damage and dysfunction. Increasing evidence has confirmed that circular RNAs...

    Li Wang, Chuanhe Wang, ... Zhijun Sun in Journal of Cardiovascular Translational Research

    Article 20 July 2023
    

11. RORA alleviates LPS-induced apoptosis of renal epithelial cells by promoting PGC-1α transcription

    Objective

    To explore the effect of RORA on LPS-induced renal epithelial cell apoptosis and the underlying mechanism.

    Methods

    LPS-treated HK-2 cells...

    Dayong Li, Guanlan Liu, Yundou Wu in Clinical and Experimental Nephrology

    Article Open access 23 February 2022
    

12. Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics

    Antagonistic antibodies targeting the inhibitory immune-checkpoint receptor PD-1 or its ligand PD-L1 are used to treat a wide range of cancer types...

    Hirohito Yamaguchi, Jung-Mao Hsu, ... Mien-Chie Hung in Nature Reviews Clinical Oncology

    Article 07 February 2022
    

13. Prioritization of family member sequencing for the detection of rare variants

    Background

    The advent of affordable sequencing has enabled researchers to discover many variants contributing to disease, including rare variants....

    Rachel Sippy, Jill M Kolesar, ... Corinne D Engelman in BMC Proceedings

    Article Open access 18 October 2016
    

14. Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

    Human sarcomas comprise a heterogeneous group of more than 50 subtypes broadly classified into two groups: bone and soft tissue sarcomas. Such...

    Anne E Sarver, Aaron L Sarver, ... Subbaya Subramanian in Laboratory Investigation

    Article 29 June 2015