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Intraoperative cerebrospinal fluid leakage and residual tumors in endoscopic transsphenoidal surgery for pituitary adenoma: risk analysis and nomogram development
BackgroundEndoscopic transsphenoidal surgery is the primary method used to treat pituitary adenomas (PAs) at present; however, this technique is...
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Pituitary apoplexy: a systematic review of non-gestational risk factors
PurposePregnancy is a known risk factor for Pituitary Apoplexy (PA) but there is a lack of consistency in the literature regarding non-gestational...
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Giant growth hormone-secreting pituitary adenomas from the endocrinologist’s perspective
ObjectivesSince giant (≥40 mm) GH-secreting pituitary adenomas are rarely encountered, data on their characteristics and treatment outcomes are...
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Clinical characteristics and therapeutic outcomes of acromegalic patients with giant growth hormone-secreting pituitary adenomas: a single-center study of 67 cases
PurposeAcromegalic patients with giant growth hormone-secreting pituitary adenomas (GHPAs) (≥ 40 mm) are relatively rare, and their clinical...
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Comparative epigenomics indicate a common origin of ectopic and intrasellar corticotroph pituitary neuroendocrine tumors/adenomas: a case report
Ectopic pituitary neuroendocrine tumors (PitNET)/adenomas are rare and diagnostically challenging extra-sellar tumors. Previous studies have...
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Prognostic implication of size on outcomes of pituitary macroadenoma: a comparative analysis of giant adenoma with non-giant macroadenoma
BackgroundDue to the differences in size and invasiveness when compared to non-giant macroadenomas (nGPAs), giant pituitary adenomas (GPAs) are...
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Two- and three-dimensional endoscopic endonasal surgery of large and giant pituitary adenomas—outcome analysis of a series of 62 patients from a single pituitary center
To analyze the perioperative course and clinical outcome of patients with large (lPA) and giant (gPA) pituitary adenoma who underwent endoscopic...
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Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement
This Consensus Statement from an international, multidisciplinary workshop sponsored by the Pituitary Society offers evidence-based graded consensus...
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Pituitary function at presentation and following therapy in patients with non-functional pituitary macroadenomas: a single centre retrospective cohort study
BackgroundNon-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional...
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Characteristics and overall survival in pediatric versus adult pituitary adenoma: a National Cancer Database analysis
ObjectivePituitary adenomas in the pediatric population are extremely rare, resulting in limited information in the literature on these patients. In...
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Pituitary surgery in Cushing’s disease: first line treatment and role of reoperation
Cushing’s disease is the most common cause of endogenous hypercortisolemia, and transsphenoidal surgery remains the first line therapy for removal of...
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Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life
PurposeThe aim of this prospective longitudinal study was to assess both subjective quality of life using questionnaires and objective examination of...
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The hallmarks of cancer… in pituitary tumors?
Over 20 years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation....
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Germline AIP variants in sporadic young acromegaly and pituitary gigantism: clinical and genetic insights from a Han Chinese cohort
PurposeVariants in the Aryl hydrocarbon receptor-interacting protein ( AIP ) gene have been identified in sporadic acromegaly and pituitary gigantism,...
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Clinical presentation and recurrence of pituitary neuroendocrine tumors: results from a single referral center in Colombia
IntroductionPituitary neuroendocrine tumors (PitNETs) represent 15–18.2% of all intracranial tumors. Their clinical presentation can range from...
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Association of different pathologic subtypes of growth hormone producing pituitary adenoma and remission in acromegaly patients: a retrospective cohort study
BackgroundRegarding the inconclusive results of previous investigations, this study aimed to determine the association between pathology, as a...
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Anterior-posterior diameter is a key driver of resectability and complications for pituitary adenomas with suprasellar extension in endoscopic transsphenoidal surgery
BackgroundAs endoscopic transsphenoidal approaches are more routinely selected for progressively larger pituitary adenomas with parasellar extension,...
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Aggressive nonfunctioning pituitary neuroendocrine tumors
Nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) are tumors that are not associated with clinical evidence of hormonal hypersecretion....
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Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis
BackgroundSurgical resection is the main treatment for symptomatic nonfunctioning pituitary adenomas (NFPA). We aimed to analyze the impact of...
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Frailty does not preclude surgical success after endoscopic transsphenoidal surgery for pituitary adenomas
IntroductionFrailty is a state of physiological vulnerability that negatively influences surgical outcomes. The effect of frailty on pituitary...
