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Anaphylaxis to drug excipients
In addition to the therapeutic agent, drugs contain excipients such as stabilizers, preservatives, solubilizers, or dyes, some of which are identical...
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New Challenges in Drug Allergy: the Resurgence of Excipients
Purpose of ReviewAllergy to excipients is a cause of multidrug allergy and if it is not taken into account, it can lead to unexpected severe...
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Impact of Latanoprost Antiglaucoma Eyedrops and Their Excipients on Toxicity and Healing Characteristics in the Ex Vivo Eye Irritation Test System
IntroductionCorneal epithelial toxicity and delayed healing process have already been attributed to preservatives or some excipients. We study the...
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Effect of mineral excipients on processing traditional Chinese medicines: an insight into the components, pharmacodynamics and mechanism
Traditional Chinese medicines are an important class of natural products mainly derives from animals, plants and minerals, most of which need to be...
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Application of SeDeM Expert System in the development of novel directly compressible co-processed excipients via co-processing
BackgroundComputer-aided formulation design is gaining fantastic attention in chemical engineering of high functionality pharmaceutical materials for...
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Sulbactam pivoxil powder attributes and compatibility study with excipients
BackgroundSulbactam pivoxil is an irreversible β-lactamase inhibitor that can be used with β-lactam antibiotics to improve antibacterial therapy by...
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Physicochemical compatibility studies of triclosan and flurbiprofen with excipients of pharmaceutical formulation using binary, ternary, and multi-combination approach
BackgroundThe aim of the study was to evaluate the suitability of triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan...
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Application of data-intelligence algorithms for modeling the compaction performance of new pharmaceutical excipients
BackgroundPharmaceutical excipient development is an extensive process requiring a series of pre-formulation studies to evaluate their performance....
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What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
Most medicines are white bitter powders that are formulated as tablets and capsules but cough medicines are an exception where the taste and...
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Design of mobile and website health application devices for drug tolerability in hereditary fructose intolerance
BackgroundHereditary fructose intolerance (HFI) is a rare metabolic disease caused by aldolase B deficiency. The aim of our study was to analyse...
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Anaphylaxis to additives in vaccines
Anaphylaxis in connection with the administration of vaccines occurs only very rarely. Triggers of immunoglobulin IgE-mediated and non-IgE-mediated...
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Do generic drugs cause hypersensitivity?
Generic drugs may differ from brand-name drugs in nature and quantity of excipients. Hypersensitivity to generic drugs is a subject of growing...
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Utilisation of Mangifera indica plant extracts and parts in antimicrobial formulations and as a pharmaceutical excipient: a review
BackgroundAntimicrobial resistance and the environmental threat posed by some synthetic antimicrobial agents necessitate more research into...
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Allergological study in patients vaccinated against COVID-19 with suspected allergic reactions
BackgroundOne of the main barriers to vaccination against SARS-CoV-2 is the fear of develo** hypersensitivity reactions to any of its components....
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A prediction model based on artificial intelligence techniques for disintegration time and hardness of fast disintegrating tablets in pre-formulation tests
BackgroundThe pharmaceutical industry is continually striving to innovate drug development and formulation processes. Orally disintegrating tablets...
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Carboxymethylcellulose excipient allergy: a case report
BackgroundExcipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties of low toxicity and...
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Improvement of Intranasal Drug Delivery with Intravail® Alkylsaccharide Excipient as a Mucosal Absorption Enhancer Aiding in the Treatment of Conditions of the Central Nervous System
Intranasal drug administration is a commonly used route for therapeutic formulations, but there may be challenges associated with a lack of...
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AstraZeneca ChAdOx1-S COVID-19 vaccine can be safely administered in patients with EDTA allergy
BackgroundImmediate hypersensitivity reactions to COVID-19 vaccines have been postulated to be linked to their excipients, such as polyethylene...