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Learning health systems and evidence ecosystems: a perspective on the future of evidence-based medicine and evidence-based guideline development
Despite forming the cornerstone of modern clinical practice for decades, implementation of evidence-based medicine at scale remains a crucial...
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A rare partnership: patient community and industry collaboration to shape the impact of real-world evidence on the rare disease ecosystem
People with rare lysosomal storage diseases face challenges in their care that arise from disease complexity and heterogeneity, compounded by many...
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Virtual fitness buddy ecosystem: a mixed reality precision health physical activity intervention for children
6–11-year-old children provide a critical window for physical activity (PA) interventions. The Virtual Fitness Buddy ecosystem is a precision health...
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Analysing the performance of a health innovation ecosystem in the COVID-19 crisis: complexity and chaos theory perspective
BackgroundThis research delves into the complexity management of collaborative networks and interorganizational systems in the health innovation...
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International Responses to Prevention Intervention Research During Human Ecosystem Disruptions: A Commentary on the Special Issue of Prevention Science
The purpose of this commentary on the special issue of Prevention Science , “International Responses to Prevention Intervention Research During Human...
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Neglected tropical diseases risk correlates with poverty and early ecosystem destruction
BackgroundNeglected tropical diseases affect the most vulnerable populations and cause chronic and debilitating disorders. Socioeconomic...
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A human-centered, health data-driven ecosystem
New forms of digital care are introducing new methods of communication, care delivery, data sharing, and access to health information. The internet...
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The analysis of National Health Accounts and financial communications network in Iran health insurance ecosystem
BackgroundOne of the major reforms in the health system of any country is the financing reform. Network analysis as a practical method for...
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African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa
Hypertension is a leading preventable and controllable risk factor for cardiovascular and cerebrovascular diseases and the leading preventable risk...
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Introduction to the Special Issue: International Responses to Prevention Intervention Research During Human Ecosystem Disruptions
For decades, human ecosystem disruptions (HEDs), including pandemics, natural disasters, and socio-economic crises, have shaped national and...
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Real World Evidence: methodological issues and opportunities from the European Health Data Space
The current Evidence-Based-Medicine (EBM) approach is generally based on data coming from Randomized Clinical Trials or and, epidemiological...
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Rigorous and rapid evidence assessment in digital health with the evidence DEFINED framework
Dozens of frameworks have been proposed to assess evidence for digital health interventions (DHIs), but existing frameworks may not facilitate DHI...
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The influence of the vaginal ecosystem on vaginitis, bacterial vaginosis, and sexually transmitted diseases: an epidemiological study and literature review
PurposeThis study aimed to demonstrate the correlation between altered balance of the vaginal ecosystem and increased risk of vaginitis, bacterial...
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Correlation between use of different type protective facemasks and the oral ecosystem
BackgroundSpread worldwide through droplets, the Virus Sars-Cov-19 has caused a global health emergency alarm. In order to limit its spread, the use...
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Development and validation of a computed tomography–based immune ecosystem diversity index as an imaging biomarker in non-small cell lung cancer
ObjectivesTo date, there are no data on the noninvasive surrogate of intratumoural immune status that could be prognostic of survival outcomes in...
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Rethinking the path from evidence to decision-making
Evidence-informed decision-making is increasingly recognized as a standard for policymaking in many fields, including public health. However, many...
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Exploring the feasibility of using the ICER Evidence Rating Matrix for Comparative Clinical Effectiveness in assessing treatment benefit and certainty in the clinical evidence on orphan therapies for paediatric indications
BackgroundThe evaluation of clinical evidence takes account of health benefit (efficacy and safety) and the degree of certainty in the estimate of...
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Features of databases that supported searching for rapid evidence synthesis during COVID-19: implications for future public health emergencies
BackgroundAs evidence related to the COVID-19 pandemic surged, databases, platforms, and repositories evolved with features and functions to assist...
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The relationship between methodological quality and the use of retracted publications in evidence syntheses
BackgroundEvidence syntheses cite retracted publications. However, citation is not necessarily endorsement, as authors may be criticizing or refuting...
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Promise of Real-World Evidence for Patient Centricity in Gulf Cooperation Council Countries: Call to Action
Presently, Gulf Cooperation Council countries are lagging in the generation of real-world data and use of real-world evidence for patient-centered...
