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Nontargeted metabolomics reveals the potential mechanism underlying the association between birthweight and metabolic disturbances
AimsThe aim of this study was to characterize the metabolites associated with small- and large-gestational-age newborns in maternal and cord blood,...
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High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer
Estrogen receptor alpha (ER)-positive breast cancer is commonly treated with endocrine therapies, including antiestrogens that bind and inhibit ER...
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Hypertension in Women: Impact of Contraception, Fertility, and Hormone Treatment
Purpose of ReviewThis review will summarize the current literature assessing the relationship between hypertension and contraception, fertility,...
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Chorio-retinal vessel density in women affected by functional hypothalamic amenorrhea: a monocentric observational cross-sectional study to evaluate the impact of hypoestrogenism on chorio-retinal vascularization
PurposeFunctional hypothalamic amenorrhea (FHA) is characterized by an estrogen deficiency which in turn can cause vascular dysfunction. The aim of...
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The efficacy of oxytocin gel in postmenopausal women with vaginal atrophy: an updated systematic review and meta-analysis
BackgroundGenitourinary syndrome of menopause (GSM) is a common and disturbing issue in the postmenopausal period. Unlike vasomotor symptoms, it has...
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Low prolactin level identifies hypoactive sexual desire disorder women with a reduced inhibition profile
PurposeData on the role of prolactin (PRL) in the physiologic range in the female sexual response are scanty. We aimed at investigating the...
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STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells
BackgroundIn mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of...
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Cognitive Problems in Perimenopause: A Review of Recent Evidence
Purpose of ReviewTo review recent research regarding cognitive problems during perimenopause, including which menopause-related symptoms, demographic...
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Associations of reproductive factors with postmenopausal follicle stimulating hormone
PurposeRecent studies have suggested that higher postmenopausal follicle stimulating hormone (FSH) may be associated with lower risk of diabetes....
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Prolonging the time of progesterone supplementation to improve the pregnancy outcomes of single day 6 blastocyst transfer in frozen-thawed cycles: study protocol for a randomized controlled trial
BackgroundInfertility is one of the most important and underappreciated reproductive health problems in develo** countries. Currently, in vitro...
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The clinical trial of alternative relugolix administration for uterine leiomyoma prior to surgically treatment: a study protocol for Non-Adverse Relugolix Administration (NARA) trial
BackgroundUterine leiomyomas are common for reproductive-aged women and affect women’s quality of life due to heavy menstrual bleeding or...
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Perimenopausal Effects of Estradiol on Anhedonia and Psychosis Study (PEEPs): study protocol for a neural and molecular mechanistic clinical trial
BackgroundThe perimenopausal transition is accompanied by psychiatric symptoms in over 10% of women. Symptoms commonly include depressed mood and...
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Mineralocorticoid receptor blockade attenuates hyperandrogenic metabolic dysregulation in letrozole-induced PCOS rat model
PurposePolycystic ovarian syndrome (PCOS) is a metabolic syndrome associated with mineralocorticoid receptor (MR) activation, which causes...
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A Systematic Review of Autoimmune Oophoritis Therapies
Autoimmune primary ovarian insufficiency (POI) is a devastating disease with limited clinical guidance. The objective of this systematic review was...
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Oral combined hormonal contraceptive associated with protection against allodynia in migraine in a cross-sectional study
IntroductionFor the most part, migraine afflicts young women who often need to use the hormonal contraceptive method.
ObjectiveTo evaluate the...
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PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERα
The over-activation of ERα signaling is regarded as the major driver for luminal breast cancers, which could be effective controlled via selective...
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Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level
ObjectiveKeratoconus (KC) is a condition characterized by progressive corneal steepening and thinning. However, its pathophysiological mechanism...
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Metabolic effects of estradiol versus testosterone in complete androgen insensitivity syndrome
PurposeTo study differences in metabolic outcomes between testosterone and estradiol replacement in probands with complete androgen insensitivity...
