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SARS-CoV-2 variants, immune escape, and countermeasures
Coronavirus disease 2019 (COVID-19) has become a global pandemic disease. SARS-CoV-2 variants have aroused great concern and are expected to continue...
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Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants
SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity changes and immune escape. The recent emerging SARS-CoV-2...
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Modelling COVID-19 transmission dynamics in Laos under non-pharmaceutical interventions, vaccination, and replacement of SARS-CoV-2 variants
BackgroundUnderstanding how the COVID-19 pandemic evolved under control measures is crucial to tackle the SARS-CoV-2 virus spread. Laos, a country...
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Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses
A steep rise in Omicron reinfection cases suggests that this variant has increased immune evasion ability. To evaluate its antigenicity relationship...
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Examining the Strength of the Association Between Problem Gambling and Gambling to Escape. A Systematic Review and Meta-Analysis
Gambling to escape is often purported to play a central role in the maintenance of problem gambling. However, the strength and consistency this...
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SARS-CoV-2 BW lineage, a fast-growing Omicron variant from southeast Mexico bearing relevant escape mutations
PurposeThe swift expansion of the BW.1 SARS-CoV-2 variant coincided with a rapid increase of COVID-19 cases occurring in Southeast Mexico in October,...
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Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge
Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2...
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Investigation of the immune escape mechanism of Treponema pallidum
BackgroundSyphilis is a chronic sexually transmitted disease caused by Treponema pallidum subspecies pallidum ( T. pallidum ), which is a public...
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HLA and tumour immunology: immune escape, immunotherapy and immune-related adverse events
PurposeAs molecules responsible for presenting antigens to T lymphocytes, leukocytes antigens (HLAs) play a vital role in cancer immunology. This...
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SARS-CoV-2 journey: from alpha variant to omicron and its sub-variants
The COVID-19 pandemic has affected hundreds of millions of individuals and caused more than six million deaths. The prolonged pandemic duration and...
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Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma
BackgroundHypoxia is a hallmark of cancer, and is closely intertwined with tumor immune evasion. Circular RNAs (circRNAs) have been implicated in...
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Molecular landscape of immune pressure and escape in aplastic anemia
Idiopathic aplastic anemia (IAA) pathophysiology is dominated by autoreactivity of human leukocyte antigen (HLA)-restricted T-cells against antigens...
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Immunological and metabolic characteristics of the Omicron variants infection
The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here,...
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Genomic epidemiology of SARS-CoV-2 variants during the first two years of the pandemic in Colombia
BackgroundThe emergence of highly transmissible SARS-CoV-2 variants has led to surges in cases and the need for global genomic surveillance. While...
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Evolution and implications of SARS-CoV-2 variants in the post-pandemic era
SARS-CoV-2, the cause of the COVID-19 pandemic, has introduced a challenging era characterized by the persistent emergence of subvariants. Even after...
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MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
BackgroundGene variants have been identified in patients with familial or sporadic idiopathic pulmonary fibrosis (IPF). These variants may partially...
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Analysis of SARS-CoV-2 Emergent Variants Following AZD7442 (Tixagevimab/Cilgavimab) for Early Outpatient Treatment of COVID-19 (TACKLE Trial)
IntroductionAZD7442 (tixagevimab/cilgavimab) comprises neutralising monoclonal antibodies (mAbs) that bind to distinct non-overlap** epitopes on...
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HA gene amino acid mutations contribute to antigenic variation and immune escape of H9N2 influenza virus
Based on differences in the amino acid sequence of the protein haemagglutinin (HA), the H9N2 avian influenza virus (H9N2 virus) has been clustered...
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Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo
Defective interfering genes (DIGs) are short viral genomes and interfere with wild-type viral replication. Here, we demonstrate that the new designed...
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An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants
The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid accumulation of mutations, posing significant challenges to the...
