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Mutations of epigenetic modifier genes predict poor outcome in adult acute lymphoblastic leukemia
Epigenetic modifier (EM) genes play important roles in the occurrence and progression of acute lymphoblastic leukemia (ALL). However, the prognostic...
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Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
Isocitrate dehydrogenase (IDH) mutations are found in 20% of acute myeloid leukemia (AML) patients. However, only 30–40% of the patients respond to...
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Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism
PurposeThe elevated frequency of discordance for congenital hypothyroidism (CH) phenotype between monozygotic twins suggests the involvement of...
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Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways
Colorectal cancer (CRC) is a complex disease characterized by genetic and epigenetic alterations, playing a crucial role in its development and...
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Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways
Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are...
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Epigenetic regulation by ASXL1 in myeloid malignancies
Myeloid malignancies are clonal hematopoietic disorders that are comprised of a spectrum of genetically heterogeneous disorders, including...
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A study on genotypes and phenotypes of short stature caused by epigenetic modification gene variants
Mendelian disorders of the epigenetic machinery (MDEMs) are caused by genetic mutations, a considerable fraction of which are associated with...
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Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatment
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with alterations in genetic expression and epigenetic modifications. In recent years,...
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Obesity-associated epigenetic alterations and the obesity-breast cancer axis
Both breast cancer and obesity can regulate epigenetic changes or be regulated by epigenetic changes. Due to the well-established link between...
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Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
Hematologic malignancies are one of the most common cancers, and the incidence has been rising in recent decades. The clinical and molecular features...
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Biological and clinical significance of epigenetic alterations in B-cell lymphomas
Recent advances in genetic analysis of hematopoietic tumors have led to the discovery of enzyme abnormalities that control epigenetic changes....
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Epigenetic alterations and advancement of lymphoma treatment
Lymphomas, complex and heterogeneous malignant tumors, originate from the lymphopoietic system. These tumors are notorious for their high recurrence...
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BAP1 in cancer: epigenetic stability and genome integrity
Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1...
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Basic Epigenetic Mechanisms of Aging
AbstractThe process of aging is a complex biological phenomenon that is influenced by multiple factors, including genetics, environment, and...
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Novel epigenetic molecular therapies for imprinting disorders
Genomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their...
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Epigenetic modifications in the development of bronchopulmonary dysplasia: a review
AbstractWhile perinatal medicine advancements have bolstered survival outcomes for premature infants, bronchopulmonary dysplasia (BPD) continues to...
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Epigenetic Alternations in Endometrial Cancer; Future Strategies for Treatment
AimThe incidence of endometrial cancer (EC) is increasing globally, with a projected continued rise in the number of affected individuals,...
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Hypomethylating agents (HMAs) show benefit in AML rather than in intermediate/high-risk MDS based on genetic mutations in epigenetic modification (EMMs): from a retrospective study
Since HMAs were recommended for treatments in AML and MDS, we wondered whether HMAs could provide similar benefit to AML and intermediate/high-risk...
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Epigenetic and epitranscriptomic regulation of axon regeneration
Effective axonal regeneration in the adult mammalian nervous system requires coordination of elevated intrinsic growth capacity and decreased...
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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin...
