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Epigenetic markers in the embryonal germ cell development and spermatogenesis
Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis....
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Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatment
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with alterations in genetic expression and epigenetic modifications. In recent years,...
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ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer
ObjectiveCisplatin (CDDP)-based chemotherapy is a first-line, drug regimen for muscle-invasive bladder cancer (BC) and metastatic bladder cancer....
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Epigenetic alterations and advancement of lymphoma treatment
Lymphomas, complex and heterogeneous malignant tumors, originate from the lymphopoietic system. These tumors are notorious for their high recurrence...
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Epigenetic modifications in the development of bronchopulmonary dysplasia: a review
AbstractWhile perinatal medicine advancements have bolstered survival outcomes for premature infants, bronchopulmonary dysplasia (BPD) continues to...
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Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways
Colorectal cancer (CRC) is a complex disease characterized by genetic and epigenetic alterations, playing a crucial role in its development and...
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Epigenetic and epitranscriptomic regulation of axon regeneration
Effective axonal regeneration in the adult mammalian nervous system requires coordination of elevated intrinsic growth capacity and decreased...
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Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, plays a pivotal role in...
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Novel epigenetic molecular therapies for imprinting disorders
Genomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their...
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Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin...
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Targeting epigenetic regulators to overcome drug resistance in cancers
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation is a heritable change in gene expressions...
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Pancreatic Cancer: Genetic Conditions and Epigenetic Alterations
BackgroundPancreatic cancer is a lethal proliferative disease driven by multiple genetic and epigenetic alterations. Microarrays and omics-based...
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BAP1 in cancer: epigenetic stability and genome integrity
Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1...
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Epigenetic regulation of aging: implications for interventions of aging and diseases
Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These...
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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but...
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Epigenetic Dysregulation in Autoimmune and Inflammatory Skin Diseases
Epigenetics is the study of heritable, reversible gene expression patterns that do not originate from alterations in the DNA sequence. Epigenetic...
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Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy
Pancreatic adenocarcinoma is a lethal cancer with poor response to chemotherapy and immune checkpoint inhibitors. Recent studies suggest that...
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Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
Autophagy is a conserved lysosomal degradation pathway where cellular components are dynamically degraded and re-processed to maintain physical...
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Biological and clinical significance of epigenetic alterations in B-cell lymphomas
Recent advances in genetic analysis of hematopoietic tumors have led to the discovery of enzyme abnormalities that control epigenetic changes....
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Emerging epigenetic targets in rheumatoid arthritis
Rheumatoid arthritis is a complex disorder that is characterized by irreversible and progressive destructions of joints, but its exact etiology...
