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EpCAM tumor specificity and proteoform patterns in urothelial cancer
BackgroundThe role of the epithelial cell adhesion molecule (EpCAM) in cancer is still unclear. EpCAM cleavage through regulated intramembrane...
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Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors
PurposeRadical resection is paramount for curative oncological surgery. Fluorescence-guided surgery (FGS) aids in intraoperative identification of...
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Comparison of mammosphere formation from stem-like cells of normal breast, malignant primary breast tumors, and MCF-7 cell line
BackgroundMammosphere formation assay has become a versatile tool to quantify the activity of putative breast cancer stem cells in non-adherent in...
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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET
BackgroundPretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen...
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Characterization of Hyaluronan Localization in the Develo** Mammary Gland and Mammary Tumors
The extracellular matrix (ECM) is biochemically and biomechanically important for the structure and function of the mammary gland, which undergoes...
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Monogenic mutations in four cases of neonatal-onset watery diarrhea and a mutation review in East Asia
BackgroundInfants with neonatal-onset diarrhea present with intractable diarrhea in the first few weeks of life. A monogenic mutation is one of the...
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Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma
Metastasis and recurrence account for 95% of deaths from nasopharyngeal carcinoma (NPC). Cancer stem cells (CSCs) are regarded as one of the main...
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Emerging new therapeutic antibody derivatives for cancer treatment
Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell...
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Diagnostic liquid biopsy biomarkers in renal cell cancer
The clinical presentation of renal cell cancer (RCC) is shifting towards incidental and early detection, creating new challenges in RCC diagnosis....
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A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening
Endometrium-related malignancies including uterine endometrioid carcinoma, ovarian clear cell carcinoma and ovarian endometrioid carcinoma are major...
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The functional and clinical roles of liquid biopsy in patient-derived models
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters in blood, as well as the detection of, cell-free DNA...
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Addiction to protein kinase Cɩ due to PRKCI gene amplification can be exploited for an aptamer-based targeted therapy in ovarian cancer
PRKCI , the gene for protein kinase Cι (PKCι), is frequently amplified in ovarian cancer and recent studies have shown that PKCι participates in ovary...
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„Liquid biopsy“ – schon reif für Therapieentscheidungen?
Liquid biopsy (LB)-based methods enable less invasive and repeatable sample collection from various body fluids of cancer patients including blood,...
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An overview of current development and barriers on liquid biopsy in patients with early-stage non-small-cell Lung cancer
PurposeLiquid biopsy is a promising technological method in patient management of early-stage non-small-cell lung cancer (NSCLC). The detection...
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N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity of cancer cells and their...
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A method for isolating and culturing ectopic epithelial and stromal cells to study human adenomyosis
PurposeAlthough adenomyosis is a common and benign gynecological disease, the specific pathogenesis of this condition is yet to be fully elucidated....
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Liquid biopsy in ovarian cancer: advantages and limitations for prognosis and diagnosis
Ovarian cancer (OC) is a highly fatal gynecologic malignancy, often diagnosed at an advanced stage which presents significant challenges for disease...
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Nanomedicine in cancer therapy
Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted...
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Exosomes in diagnostic and therapeutic applications of ovarian cancer
Ovarian cancer accounts for more deaths than any other female reproductive tract cancer. The major reasons for the high mortality rates include...
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Longitudinal tracking of circulating rare events in the liquid biopsy of stage III–IV non-small cell lung cancer patients
In the United States, lung cancer is the second most common type of cancer with non-small cell lung cancer (NSCLC) encompassing around 85% of total...
