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A novel mouse model of intestinal neuronal dysplasia: visualization of the enteric nervous system
PurposeIntestinal neuronal dysplasia (IND) is a congenital anomaly affecting gastrointestinal neural innervation, but the pathogenesis remains...
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A review on recent advances on nobiletin in central and peripheral nervous system diseases
In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral...
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Disorders of the enteric nervous system — a holistic view
The enteric nervous system (ENS) is the largest division of the peripheral nervous system and closely resembles components and functions of the...
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Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice
BackgroundLeucine-rich repeat kinase 2 is a molecule that is responsible for familial Parkinson’s disease. Our previous findings revealed that...
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Visualization of the human enteric nervous system by probe confocal laser endomicroscopy: a first real-time observation of Hirschsprung’s disease and allied disorders
BackgroundOur group previously proved that the human enteric nervous system can be visualized with confocal laser endomicroscopy after topical...
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Crosstalk Between the Nervous System and Systemic Organs in Acute Brain Injury
Organ crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a...
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Intrauterine exposure to oxidative stress induces caspase-1-dependent enteric nerve cell pyroptosis
PurposeThis study determined whether oxidative stress causes the developmental abnormalities of the enteric nervous system during the embryonic...
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Imaging of central nervous system emergencies in oncology
Central nervous system (CNS) may be predisposed to devastating complications in cancer patients which may add to morbidity and mortality in this...
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Nicotinamide Riboside Improves Enteric Neuropathy in Streptozocin-Induced Diabetic Rats Through Myenteric Plexus Neuroprotection
BackgroundDiabetes Mellitus causes a systemic oxidative stress due in part to the hyperglycemia and the reactive oxygen species generated. Up to 75%...
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Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility
The gastrointestinal tract is the only internal organ to have evolved with its own independent nervous system, known as the enteric nervous system...
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Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam
An estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of...
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Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy
Environmental enteric dysfunction (EED) is a subclinical syndrome of intestinal inflammation, malabsorption and barrier disruption that is highly...
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GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
BackgroundHirschsprung disease (HSCR) is a congenital intestinal disease characterised by functional obstruction of the colon. Herein, we...
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Investigating the development of the autonomic nervous system in infancy through pupillometry
We aim to investigate early developmental trajectories of the autonomic nervous system (ANS) as indexed by the pupillary light reflex (PLR) in...
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In vitro investigation of the differentiation of enteric neural crest-derived cells following transplantation of aganglionic gut in a mouse model
PurposeCell therapy is a promising approach to treat enteric neuropathies such as Hirschsprung disease (HD). Recent studies have reported that...
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Structural and functional connections between the autonomic nervous system, hypothalamic–pituitary–adrenal axis, and the immune system: a context and time dependent stress response network
The autonomic nervous system (ANS), hypothalamic–pituitary–adrenal (HPA) axis, and immune system are connected anatomically and functionally. These...
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The impact of the recipient intestinal site on the differentiation of transplanted enteric neural crest cells
PurposeIt has long been established that the failure of enteric neural crest cells (ENCCs) to colonize the entire gut results in aganglionosis at the...
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Autonomic nervous system involvement in chronic inflammatory demyelinating polyradiculoneuropathy: a literature review
Background and aimsAlthough dysautonomia is a well-recognized complication of acute demyelinating polyradiculoneuropathy, it is rarely reported and...
