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Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
Preclinical evidence suggests that antidepressants (ADs) may differentially influence mitochondrial energetics. This study was conducted to...
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The Role of Bone Cell Energetics in Altering Bone Quality and Strength in Health and Disease
Purpose of ReviewBone quality and strength are diminished with age and disease but can be improved by clinical intervention. Energetic pathways are...
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Map** the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery
BackgroundObesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease. This prospective...
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4D flow cardiovascular magnetic resonance derived energetics in the Fontan circulation correlate with exercise capacity and CMR-derived liver fibrosis/congestion
AimThis study explores the relationship between in vivo 4D flow cardiovascular magnetic resonance (CMR) derived blood flow energetics in the total...
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Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse
BackgroundPhosphorus cardiovascular magnetic resonance spectroscopy ( 31 P-CMRS) has emerged as an important tool for the preclinical assessment of...
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Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques
The role of inflammation in cardiovascular pathophysiology has gained a lot of research interest in recent years. Cardiovascular Magnetic Resonance...
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Energetics of Floor Gymnastics: Aerobic and Anaerobic Share in Male and Female Sub-elite Gymnasts
BackgroundArtistic gymnastics is a popular Olympic discipline where female athletes compete in four and male athletes in six events with floor...
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Impact of pulmonary artery flow distribution on Fontan hemodynamics and flow energetics
BackgroundWith improved life expectancy following Fontan palliation, there is an increasing population of patients with a total cavopulmonary...
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Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study
BackgroundEmpagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that has demonstrated cardiovascular and renal protection in patients...
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Energetics and Biomechanics of Running Footwear with Increased Longitudinal Bending Stiffness: A Narrative Review
In the wake of the quest to break the 2-h marathon barrier, carbon-fiber plates have become commonplace in marathon racing shoes. Despite the...
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Tetralogy of Fallot regurgitation energetics and kinetics: an intracardiac flow analysis of the right ventricle using computational fluid dynamics
Repaired Tetralogy of Fallot (rTOF) patients suffer from pulmonary regurgitation and may require pulmonary valve replacement (PVR). Cardiac magnetic...
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Impact of 4D-Flow CMR Parameters on Functional Evaluation of Fontan Circulation
We sought to evaluate the potential clinical role of 4D-flow cardiac magnetic resonance (CMR)-derived energetics and flow parameters in a cohort of...
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Myocardial Fatigue at a Glance
Expanding on the modern lexicon of heart failure (HF), the novel mechano-energetic concept of myocardial fatigue describes a transiently...
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Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
Mitochondrial creatine kinase (Mt-CK) is a major determinant of cardiac energetic status and is down-regulated in chronic heart failure, which may...
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A systematic review of the relationship between muscle oxygen dynamics and energy rich phosphates. Can NIRS help?
BackgroundPhosphocreatine dynamics provide the gold standard evaluation of in-vivo mitochondrial function and is tightly coupled with oxygen...
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Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case–control study
BackgroundThe underlying pathophysiology of post-coronavirus disease 2019 (long-COVID-19) syndrome remains unknown, but increased cardiometabolic...
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SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
SMYD1, a striated muscle-specific lysine methyltransferase, was originally shown to play a key role in embryonic cardiac development but more...
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Computational Fluid Dynamic Assessment of Patients with Congenital Heart Disease from 3D Rotational Angiography
For congenital heart disease patients, multiple imaging modalities are needed to discern anatomy and functional information such as differential...
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Is simultaneous bilateral total hip arthroplasty deleterious in a biomechanical point of view? A comparative gait analysis study
PurposeUni- or bilateral hip osteoarthritis is a common disease generating pain, stiffness, and functional disabilities. Changes in the normal...
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Profiling the Biomechanical Responses to Workload on the Human Myocyte to Explore the Concept of Myocardial Fatigue and Reversibility: Rationale and Design of the POWER Heart Failure Study
It remains unclear why some patients develop heart failure without evidence of structural damage. One theory relates to impaired myocardial...