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The role of endotoxin in septic shock
Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7...
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Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2/HO-1 signaling pathway
PurposeEndotoxin-induced acute lung injury (ALI) is a severe disease caused by an imbalanced host response to infection. It is necessary to explore...
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Identification of novel biomarkers of acute phase response in chickens challenged with Escherichia coli lipopolysaccharide endotoxin
BackgroundThe chicken’s inflammatory response is an essential part of the bird’s response to infection. A single dose of Escherichia coli ( E. coli )...
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Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis
Changes in the milk microbiota during the course of mastitis are due to the nature of a sporadic occurring disease difficult to study. In this study...
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Milk fat miRNome changes in response to LPS challenge in Holstein cows
Mastitis is an inflammatory disease in dairy cows, causing economic losses and reducing animal welfare. In order to contribute for the discovery of...
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The effect of an acute aspirin challenge on intestinal permeability in healthy adults with and without prophylactic probiotic consumption: a double-blind, placebo-controlled, randomized trial
BackgroundHealthy individuals may experience increases in intestinal permeability after chronic or acute use of non-steroidal anti-inflammatory...
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Decreased ubiquitin modifying enzyme A20 associated with hyper-responsiveness to ovalbumin challenge following intrauterine growth restriction
BackgroundIntrauterine growth restriction (IUGR) is strongly correlated with an increased risk of asthma later in life. Farm dust protects mice from...
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The Effect of Gut-Training and Feeding-Challenge on Markers of Gastrointestinal Status in Response to Endurance Exercise: A Systematic Literature Review
BackgroundNutrition during exercise is vital in sustaining prolonged activity and enhancing athletic performance; however, exercise-induced...
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Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers—with reduced intestinal barrier loss in female
ObjectiveTrauma is the most common cause of death among young adults. Alcohol intoxication plays a significant role as a cause of accidents and as a...
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The influence of equine body weight gain on inflammatory cytokine expressions of adipose tissue in response to endotoxin challenge
BackgroundHuman obesity is linked with systemic inflammation. However, it is still controversial if equines produce more inflammatory cytokines with...
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Lack of CD34 delays bacterial endotoxin-induced lung inflammation
BackgroundCD34, a pan-selectin binding protein when glycosylated, has been shown to be involved in leukocyte migration to the site of inflammation....
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Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study
Increased inflammation in major depressive disorder (MDD) has been associated with low functional connectivity (FC) in corticostriatal reward...
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Increased arginine, lysine, and methionine levels can improve the performance, gut integrity and immune status of turkeys but the effect is interactive and depends on challenge conditions
Arginine (Arg), lysine (Lys), and methionine (Met) can be used to support the health status of turkeys. The present study investigated selected...
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β-defensin 118 attenuates inflammation and injury of intestinal epithelial cells upon enterotoxigenic Escherichia coli challenge
BackgroundAntimicrobial peptides including various defensins have been attracting considerable research interest worldwide, as they have potential to...
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Exhaled breath particles as a novel tool to study lipid composition of epithelial lining fluid from the distal lung
BackgroundSurfactant phospholipid (PL) composition plays an important role in lung diseases. We compared the PL composition of non-invasively...
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Systemic inflammatory response to inhaled endotoxin does not correlate with airway response
BackgroundEndotoxin is a component of particulate matter linked to respiratory disease. Our group has shown that experimental endotoxin inhalation...
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CytoSorb hemoperfusion markedly attenuates circulating cytokine concentrations during systemic inflammation in humans in vivo
BackgroundThe CytoSorb hemoadsorption device has been demonstrated to be capable of clearing inflammatory cytokines, but has not yet been shown to...
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Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway
BackgroundPesticide residues in food and environment along with airborne contaminants such as endotoxins pose health risk. Although herbicide...
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A novel alternative for pyrogen detection based on a transgenic cell line
Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals,...
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Rationale for sequential extracorporeal therapy (SET) in sepsis
AbstractSepsis and septic shock remain drivers for morbidity and mortality in critical illness. The clinical picture of patients presenting with...
