Search
Search Results
-
Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis
ObjectiveTo explore the protective effect and the underlying mechanism of silibinin (SIB), one of the active compounds from Silybum marianum (L.)...
-
Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk
BackgroundSepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better...
-
Association between endotoxemia and blood no in the portal circulation of cirrhotic patients: results of a pilot study
Pathophysiology of portal vein thrombosis (PVT) in cirrhosis is still not entirely understood. Elevated levels of lipopolysaccharides (LPS) in portal...
-
Calorie restriction ameliorates hyperglycemia, modulates the disordered gut microbiota, and mitigates metabolic endotoxemia and inflammation in type 2 diabetic rats
PurposeThe effects of calorie restriction (CR) on gut microbiota and the mechanism of CR ameliorating hyperglycemia in streptozotocin (STZ)-induced...
-
Effects of enhanced adsorption haemofiltration versus haemoadsorption in severe, refractory septic shock with high levels of endotoxemia: the ENDoX bicentric, randomized, controlled trial
BackgroundEndotoxin adsorption is a promising but controversial therapy in severe, refractory septic shock and conflicting results exist on the...
-
Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia
Aims/hypothesisTranslocation of bacterial debris from the gut causes metabolic endotoxemia (ME) that results in insulin resistance, and may be on the...
-
Are gut dysbiosis, barrier disruption, and endotoxemia related to adipose tissue dysfunction in metabolic disorders? Overview of the mechanisms involved
Recently, compelling evidence points to dysbiosis and disruption of the epithelial intestinal barrier as major players in the pathophysiology of...
-
Effect of probiotic supplementation along with calorie restriction on metabolic endotoxemia, and inflammation markers in coronary artery disease patients: a double blind placebo controlled randomized clinical trial
PurposeAlterations in the gut microbiome (dysbiosis) has been associated with increased microbial translocation, leading to chronic inflammation in...
-
Serial measurements of Paraoxonase-1 (PON-1) activity in horses with experimentally induced endotoxemia
BackgroundParaoxonase-1 (PON-1) is an antioxidant enzyme, whose activity decreases during the acute phase response in many species. Little is known...
-
Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression
Depression is one of the global leading causes of disability, but treatments remain limited and classical antidepressants were found to be...
-
High-Fat Diet Induces Disruption of the Tight Junction-Mediated Paracellular Barrier in the Proximal Small Intestine Before the Onset of Type 2 Diabetes and Endotoxemia
Background/AimA link between an impaired intestinal barrier, endotoxemia, and the pathogenesis of metabolic diseases, such as type 2 diabetes...
-
Endotoxemia and circulating bacteriome in severe COVID-19 patients
BackgroundWhen severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary bacterial infection is uncommon. However, as...
-
HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage
BackgroundLupus nephritis (LN) is an inflammatory disease of the kidneys affecting patients with systemic lupus erythematosus. Current...
-
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
Background and AimsThe triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current...
-
Mitochondrial bioenergetics links inflammation and cardiac contractility in endotoxemia
AbstractThere is current awareness about the central role of mitochondrial dysfunction in the development of cardiac dysfunction in systemic...
-
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia
Sepsis is the main cause of mortality in patients admitted to intensive care units. During sepsis, endothelial permeability is severely augmented,...
-
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
BackgroundSepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies...
-
Comparison of the effects of different calorie amounts of enteral nutrition in hypercatabolism associated with ghrelin-POMC in endotoxemic rats
BackgroundHypercatabolism often occurs in critically ill patients, and it increases infection rates and mortality in these patients. Enteral...
-
Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver
BackgroundThe developmental immaturity of the innate immune system helps explains the increased risk of infection in the neonatal period....
