Search
Search Results
-
LASSO regression shows histidine and sphingosine 1 phosphate are linked to both sepsis mortality and endothelial damage
Sepsis is a major cause of death worldwide, with a mortality rate that has remained stubbornly high. The current gold standard of risk stratifying...
-
Dysregulation of cholesterol metabolism in cancer progression
Cholesterol homeostasis has been implicated in the regulation of cellular and body metabolism. Hence, deregulated cholesterol homeostasis leads to...
-
Transcriptional dysregulation and insights into clinical implications in melanoma
Melanoma, a highly prevalent cancer worldwide, exhibits remarkable diversity and plasticity, with the adverse prognosis of advanced melanoma...
-
The genesis of cardiovascular risk in inflammatory arthritis: insights into glycocalyx shedding, endothelial dysfunction, and atherosclerosis initiation
This narrative review provides a comprehensive examination of the complex interplay between inflammatory arthritis (IA) and cardiovascular pathology....
-
Potential biomarkers used for risk estimation of pediatric sepsis-associated organ dysfunction and immune dysregulation
AbstractPediatric sepsis is a serious issue globally and is a significant cause of illness and death among infants and children. Refractory septic...
-
Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study
Takayasu arteritis (TAK) is a rare systemic vasculitis primarily affecting the aorta and its major branches. Early diagnosis is critical to prevent...
-
Dysregulation of micro-RNA 143-3p as a Biomarker of Carotid Atherosclerosis and the Associated Immune Reactions During Disease Progression
Atherosclerosis commonly remains undiagnosed until disease manifestations occur. The disease is associated with dysregulated micro(mi)RNAs, but how...
-
Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1
BackgroundSleep deprivation (SD) is a common public health problem that contributes to various physiological disorders and increases the risk of...
-
Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation of the immune system and fibrosis in the skin and...
-
Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment
BackgroundVasculopathy is the most common complication of diabetes. Endothelial cells located in the innermost layer of blood vessels are constantly...
-
A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model
Immune dysregulation plays a key role in the pathogenesis of autism. Changes occurring at the systemic level, from brain inflammation to disturbed...
-
Mononuclear Cells Negatively Regulate Endothelial Ca2+ Signaling
Endothelial Ca 2+ signaling has important roles to play in maintaining pregnancy associated vasodilation in the utero-placenta. Inflammatory...
-
Soluble urokinase plasminogen activator receptor (suPAR) in children with obesity or type 1 diabetes as a marker of endothelial dysfunction: a cross-sectional study
Pediatric obesity and type 1 diabetes mellitus (T1DM) represent two common chronic diseases associated with chronic inflammation, endothelial...
-
Inflammation, metabolic dysregulation and environmental neurotoxins and risk of cognitive decline and impairment in midlife
BackgroundAge-related declines in cognitive function may begin in midlife.
PurposeTo determine whether blood-based biomarkers of inflammation,...
-
Immune dysregulation in multiple myeloma: the current and future role of cell-based immunotherapy
Immune dysregulation is a hallmark of clinically active multiple myeloma (MM). Interactions between malignant clonal cells and immune cells within...
-
Silencing of CD147 inhibits cell proliferation, migration, invasion, lipid metabolism dysregulation and promotes apoptosis in lung adenocarcinoma via blocking the Rap1 signaling pathway
ObjectiveCD147 is an important glycoprotein that participates in the progression of diverse cancers. This study aims to explore the specific function...
-
Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin
Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the...
-
Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis
BackgroundLipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is the major constituent of the outer membrane of...
-
The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction
Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which leads to microangiopathy and macroangiopathy and ultimately...
-
The Interplay of HIV and Long COVID in Sub-Saharan Africa: Mechanisms of Endothelial Dysfunction
Purpose of ReviewLong COVID affects approximately 5 million people in Africa. This disease is characterized by persistent symptoms or new onset of...
