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High plasma levels of endosialin and cardiovascular events in patients undergoing coronary angiography
Endosialin, also known as tumor endothelial marker-1, is a transmembrane glycoprotein that plays a role in inflammation and tumor progression....
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Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8+ T cells in clear cell renal cell carcinoma
BackgroundImmune checkpoint blockade (ICB) therapy can be effective against clear cell renal cell carcinoma (ccRCC), but many patients show no...
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Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
PurposeEndosialin/tumor endothelial marker-1 (TEM1) is an attractive theranostic target expressed by the microenvironment of a wide range of tumors,...
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A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors
Background We conducted a first-in-Japanese, phase I study of ontuxizumab, a humanized, anti-endosialin monoclonal antibody, to confirm its...
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Correction to: Preclinical Evaluation and Dosimetry of [111In] CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)
In the original article, some numerical values in the following paragraph were reported incorrectly.
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Quantitative urine proteomics in pregnant women for the identification of predictive biomarkers for preeclampsia
BackgroundPreeclampsia (PE) is a life-threatening disease characterized by elevated blood pressure and proteinuria. Predictive biomarkers of PE are...
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A phase 2 study of ontuxizumab, a monoclonal antibody targeting endosialin, in metastatic melanoma
Objectives Ontuxizumab (MORAB-004) is a first-in-class monoclonal antibody that interferes with endosialin function, which is important in tumor...
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Breast-to-Brain Metastasis: from Microenvironment to Plasticity
Abstract Purpose of ReviewBrain metastasis is a significant cause of mortality in breast cancer patients and treatment options are limited. This...
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Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules
BackgroundExtrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and...
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Multi-proteomic Biomarker Risk Scores for Predicting Risk and Guiding Therapy in Patients with Coronary Artery Disease
Purpose of ReviewPatients with established coronary artery disease (CAD) are at high residual risk for adverse events, despite guideline-based...
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From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications
The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under...
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177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM-1 scFv-Fc fusion protein in soft tissue sarcoma
PurposeTEM-1 (tumor endothelial marker-1) is a single-pass transmembrane cell surface glycoprotein expressed at high levels by tumor vasculature and...
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Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy
ObjectiveMelatonin has been reported to suppress inflammation and alleviate liver fibrosis, but its effect on autophagy in liver fibrosis has not...
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Role of perivascular cells in kidney homeostasis, inflammation, repair and fibrosis
Perivascular niches in the kidney comprise heterogeneous cell populations, including pericytes and fibroblasts, with distinct functions. These...
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Effects of dietary-based weight loss interventions on biomarkers of endothelial function: a systematic review and meta-analysis
Endothelial dysfunction is closely linked to the development of atherosclerosis. This systematic review and meta-analysis reviewed the evidence on...
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TEM1 up-regulates MMP-2 and promotes ECM remodeling for facilitating invasion and migration of uterine sarcoma
ObjectivesTo explore the correlation between tumor endothelial marker 1 (TEM1) and matrix metalloproteinase 2 (MMP-2) in uterine sarcoma and their...
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Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis
Inclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory myopathies (IIM) due to its distinct clinical presentation and...
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Frozen shoulder
Frozen shoulder is a common debilitating disorder characterized by shoulder pain and progressive loss of shoulder movement. Frozen shoulder is...
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Versatile subtypes of pericytes and their roles in spinal cord injury repair, bone development and repair
Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit (NVU), pericytes play an...
