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LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies
Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 ( LRP10 ) gene have been associated with autosomal-dominant...
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Divergent Roles of KLF4 During Primordial Germ Cell Fate Induction from Human Embryonic Stem Cells
As a core transcriptional factor regulating pluripotency, Krüppel-like factor 4 (KLF4) has gained much attention in the field of stem cells during...
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Gene Repair of iPSC Line with GARS (G294R) Mutation of CMT2D Disease by CRISPR/Cas9
ObjectiveCharcot-Marie-Tooth disease (CMT) severely affects patient activity, and may cause disability. However, no clinical treatment is available...
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Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids
PTEN germline mutations account for ~0.2–1% of all autism spectrum disorder (ASD) cases, as well as ~17% of ASD patients with macrocephaly, making it...
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Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells
The degeneration of nigral (A9) dopaminergic (DA) neurons causes motor symptoms in Parkinson’s disease (PD). We use small-molecule compounds to...
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Iris-derived induced pluripotent stem cells that express GFP in all somatic cells of mice and differentiate into functional retinal neurons
When regenerated tissue is generated from induced pluripotent stem cells (iPSCs), it is necessary to track and identify the transplanted cells....
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Corneal stromal regeneration—keratoconus cell therapy: a review
BackgroundKeratoconus is a corneal ectatic disease caused by stromal thinning leading to astigmatism and progressive loss of vision. Loss of the...
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Stem cell therapy in sensorineural hearing loss: a systematic review
BackgroundDamage to the inner ear or cochlear nerve results in sensorineural hearing loss (SNHL), which is typically persistent deafness. SNHL can...
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Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans
Age increases the risk for cognitive impairment and is the single major risk factor for Alzheimer’s disease (AD), the most prevalent form of dementia...
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Induced pluripotent stem cells from homozygous Runx2-deficient mice show poor response to vitamin D during osteoblastic differentiation
Cleidocranial dysplasia (CCD) is a hereditary disorder associated with skeletal dysplasia and dental abnormalities. CCD arises from heterozygous loss...
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Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids
Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the manifestation of psychiatric symptoms in early adulthood. While...
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The Role of Large Animal Models in Cardiac Regeneration Research Using Human Pluripotent Stem Cell-Derived Cardiomyocytes
Purpose of ReviewHeart failure leads to high mortality. The failing myocardium cannot often be rescued as heart regeneration is mostly compromised by...
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Generation of Autologous Vascular Endothelial Cells for Patients with Peripheral Artery Disease
AbstractPeripheral artery disease (PAD) is a prevalent cardiovascular disease with risks of limb loss. Our objective is to establish an autologous...
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The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors
Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but otherwise maintains unknown disease origins. Unfortunately,...
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Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis
BackgroundTeratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of...
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Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem...
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Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission
Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this...
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An evidence appraisal of heart organoids in a dish and commensurability to human heart development in vivo
Stem-cell derived in vitro cardiac models have provided profound insights into mechanisms in cardiac development and disease. Efficient...
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Photobiomodulation with a wavelength > 800 nm induces morphological changes in stem cells within otic organoids and scala media of the cochlea
Photobiomodulation (PBM) is a therapeutic approach to certain diseases based on light energy. Currently, stem cells (SCs) are being considered as...
