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Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex I in mitochondria is a...
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SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by direct action on the failing heart that is independent of changes in...
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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
Primary ciliary dyskinesia (PCD) is a congenital, motile ciliopathy with pleiotropic symptoms. Although nearly 50 causative genes have been...
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Transport and barrier mechanisms that regulate ciliary compartmentalization and ciliopathies
Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs and signalling molecules that regulate developmental...
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A GATE simulation study for dosimetry in cancer cell and micrometastasis from the 225Ac decay chain
BackgroundRadiopharmaceutical therapy (RPT) with alpha-emitting radionuclides has shown great promise in treating metastatic cancers. The successive...
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Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including...
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Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain
Invasive growth of glioblastoma makes residual tumor unremovable by surgery and leads to disease relapse. Temozolomide is widely used first-line...
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Subcellular distribution of membrane lipids revealed by freeze-fracture electron microscopy
Cell membranes are composed of a large variety of lipids and proteins. While the localization and function of membrane proteins have been extensively...
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Exploring mitochondrial biomarkers for Friedreich's ataxia: a multifaceted approach
This study presents an in-depth analysis of mitochondrial enzyme activities in Friedreich's ataxia (FA) patients, focusing on the Electron Transport...
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Blood-based mitochondrial respiratory chain function in major depression
Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic...
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Lambda light chain-induced monoclonal gammopathy of renal significance, manifesting with Fanconi Syndrome and osteomalacia
BackgroundMonoclonal gammopathy of renal significance (MGRS) encompasses a heterogeneous group of kidney diseases in which a monoclonal...
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Association of mitochondrial respiratory chain enzymes with the risk and mortality of sepsis among Chinese children
BackgroundSepsis is a leading cause of pediatric morbidity and mortality worldwide. The aim of this study was to explore the association of decreased...
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Perspective: mitochondrial STAT3 in cardioprotection
Activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key cardioprotective signal not only in animal...
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Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming
Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs...
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Differences in cognition, short-chain fatty acids and related metabolites in pregnant versus non-pregnant women: a cross-sectional study
BackgroundPregnancy induces cognitive reorganization which can lead to mental disorders. The aim of this study is to determine differences in...
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Effects of different short-chain fatty acids (SCFA) on gene expression of proteins involved in barrier function in IPEC-J2
BackgroundGut microbial anaerobic fermentation produces short-chain fatty acids (SCFA), which are important substrates for energy metabolism and...
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Differential Sperm Proteomics Reveals the Significance of Fatty Acid Synthase and Clusterin in Idiopathic Recurrent Pregnancy Loss
Recurrent pregnancy loss (RPL) is a pervasive health issue affecting a large number of couples globally, which leads to increased emotional and...
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Excess branched-chain amino acids alter myotube metabolism and substrate preference which is worsened by concurrent insulin resistance
PurposeBranched-chain amino acids (BCAA) have been shown to enhance several cellular signaling pathways including protein synthesis and mitochondrial...
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Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP
Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked adrenoleukodystrophy, a rare neurodegenerative disease that...
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Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca 2+ release is essential to boost energy production in ventricular...
