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Targeting neutrophil elastase is a promising direction for future cancer treatment
Neutrophil elastase (NE) is a proteolytic enzyme released extracellular during the formation of neutrophil extracellular traps (NETs) through...
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Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model
PurposeThe elastase-induced aneurysm (EIA) model in rabbits has been proposed for translational research; however, the adjustment of aneurysm neck...
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Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways
BackgroundCommon respiratory illnesses, such as emphysema and chronic obstructive pulmonary disease, are characterized by connective tissue damage...
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Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema
BackgroundChronic obstructive pulmonary disease (COPD) is among the top 5 causes of mortality in the world and can develop as a consequence of...
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Screening for undiagnosed pancreatic exocrine insufficiency (PEI) in a cohort of diabetic patients using faecal elastase testing and PEI scoring system
IntroductionType 1 and type 2 diabetes mellitus (DM) are often accompanied by mild forms of pancreatic exocrine insufficiency (PEI). The prevalence...
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Tissue neutrophil elastase contributes to extracorporeal shock wave lithotripsy-induced kidney damage and the neutrophil elastase inhibitor, sivelestat, attenuates kidney damage with gratifying immunohistopathological and biochemical findings: an experimental study
Although the efficacy of extracorporeal shock wave lithotripsy (ESWL) has been well established within the literature, debate continues on the safety...
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Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes
BackgroundChronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that...
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Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
BackgroundIL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic...
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Budesonide/glycopyrronium/formoterol fumarate triple therapy prevents pulmonary hypertension in a COPD mouse model via NFκB inactivation
BackgroundChronic obstructive pulmonary disease (COPD) is a health problem that results in death, commonly due to the development of pulmonary...
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Assessment of Exocrine Pancreatic Function Following Bariatric/Metabolic Surgery: a Prospective Cohort Study
BackgroundExocrine pancreatic insufficiency (EPI) can be seen after bariatric/metabolic surgery. Fecal elastase level is a simple test in diagnosing...
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Functional, biological, and radiological evaluation of the pancreaticojejunal anastomosis 1 year after pancreatoduodenectomy: a prospective study
PurposeThis prospective study aimed to analyze the functional, biological, and radiological aspects of the pancreatic anastomosis 1 year after...
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Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and...
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Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis
Background and ObjectiveBrensocatib is an investigational, first-in-class, selective, and reversible dipeptidyl peptidase 1 inhibitor that blocks...
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PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model
BackgroundMigraine is a severely debilitating disorder that affects millions of people worldwide. Studies have indicated that activation of...
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Gastrectomy reduces pancreatic secretory function via pancreatic atrophy
PurposeAlthough reports suggest that the pancreatic volume decreases after gastrectomy for gastric cancer, the relationship between the pancreatic...
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Pro-resolving and pro-inflammatory fatty acid-derived mediators in sputum of stable state bronchiectasis patients
BackgroundBronchiectasis is characterized by neutrophilic inflammation and frequent exacerbations often associated with infections. Lipid mediators...
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Chemical and biological characterization of Melaleuca subulata (Cheel) Craven leaves’ volatile constituents supported by chemometric analysis and molecular docking
BackgroundThe genus Melaleuca (Myrtaceae) comprises dozens of essential oil (EO)-rich species that are appreciated worldwide for their various...
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Protective immunity in mice vaccinated with a novel elastase-1 significantly decreases Trichinella spiralis fecundity and infection
Trichinella spiralis is an important foodborne parasitic nematode that represents an enormous threat to the food safety of pork meat. The development...
