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Similarities and Differences Between Pragmatic Trials and Hybrid Effectiveness-Implementation Trials
Pragmatism in clinical trials is focused on increasing the generalizability of research findings for routine clinical care settings. Hybridism in...
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Power and sample size calculation for incremental net benefit in cost effectiveness analyses with applications to trials conducted by the Canadian Cancer Trials Group
BackgroundHistorically, a priori power and sample size calculations have not been routinely performed cost-effectiveness analyses (CEA), partly...
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An umbrella review of effectiveness and efficacy trials for app-based health interventions
Health interventions based on mobile phone or tablet applications (apps) are promising tools to help patients manage their conditions more...
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Study protocol: a core outcome set for perioperative exercise clinical effectiveness trials for lung cancer patients
BackgroundOutcome assessment in perioperative exercise trials for lung cancer is heterogeneous, often omitting those that are important and...
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Effectiveness of Prehabilitation Modalities on Postoperative Outcomes Following Colorectal Cancer Surgery: A Systematic Review of Randomised Controlled Trials
BackgroundPostoperative morbidity in patients undergoing curative colorectal cancer surgery is high. Prehabilitation has been suggested to reduce...
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A multimodal deep learning approach for the prediction of cognitive decline and its effectiveness in clinical trials for Alzheimer’s disease
Alzheimer’s disease is one of the most important health-care challenges in the world. For decades, numerous efforts have been made to develop...
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Effectiveness of photobiomodulation and orofacial myofunctional therapy in orofacial pain disorders. A systematic review of randomized control trials
Orofacial pain can significantly affect physical, psychological, and overall quality of life. This study aimed to compare the effectiveness of...
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The unrecognized role of fidelity in effectiveness-implementation hybrid trials: simulation study and guidance for implementation researchers
BackgroundEffectiveness-implementation hybrid designs are a relatively new approach to evaluate efficacious interventions in real-world settings...
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Protocol for the development of an international Core Outcome Set for treatment trials in adults with epilepsy: the EPilepsy outcome Set for Effectiveness Trials Project (EPSET)
BackgroundA Core Outcome Set (COS) is a standardised list of outcomes that should be reported as a minimum in all clinical trials. In epilepsy, the...
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Gabapentinoids for Pain: A Review of Published Comparative Effectiveness Trials and Data Submitted to the FDA for Approval
Use of the gabapentinoids for pain continues to increase. In 2018, the US Food and Drug Administration (FDA) strengthened the warnings for both...
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The effectiveness of interventions to disseminate the results of non-commercial randomised clinical trials to healthcare professionals: a systematic review
BackgroundIt is unclear how to disseminate the results of randomised controlled trials effectively to health professionals and policymakers to...
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Effectiveness of Back care education Programme among school children: a systematic review of randomized controlled trials
Study designSystematic review of Randomised controlled trials.
ObjectivesWith the increasing incidence of back pain among children and its untold...
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Gender-Specific Design and Effectiveness of Non-Pharmacological Interventions against Cognitive Decline — Systematic Review and Meta-Analysis of Randomized Controlled Trials
BackgroundThe number of people living with dementia worldwide is increasing rapidly. Preventive approaches constitute a promising strategy to counter...
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Effectiveness of visceral fascial therapy targeting visceral dysfunctions outcome: systematic review of randomized controlled trials
BackgroundFascial Therapy is an ancient and widespread practice throughout the world. These approaches are very common in osteopathic practice and...
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Efficacy and effectiveness of Herpes zoster vaccination in adults with diabetes mellitus: a systematic review and meta-analysis of clinical trials and observational studies
AimThe risk for Herpes zoster (HZ) and its complications is higher in people with diabetes mellitus (DM). Our aim is to assess efficacy and...
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Comparative effectiveness of seven interventions for chronic hepatitis D: a systematic review and network meta-analysis of randomized controlled trials
ObjectiveTo compare the effectiveness of seven major interventions [Bulevirtide (BLV), Interferon (IFN), Nucleoside analogs (NAs), BLV + IFN,...
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Effectiveness of patient decision aids in patients with advanced kidney disease: a meta-analysis based on randomized controlled trials
PurposeTo systematically evaluate the decision effectiveness of patient decision aids (PtDAs) on the decision-making effect of patients with advanced...
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Effectiveness of vestibular rehabilitation on postural balance in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
IntroductionPostural balance impairment can affect the quality of life of patients with Parkinson’s disease. Previous studies have described...
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Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials
IntroductionThis study aimed to assess the effectiveness of calcimimetics in reducing the risk of fractures in dialysis patients with secondary...
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Effectiveness of dietetic care for cancer survivors in the primary care setting: A systematic review and meta-analysis of randomized controlled trials
PurposeNutrition plays an important role in cancer survivorship. This systematic review and meta-analysis aim to critically assess and quantify the...
