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New score to predict COVID-19 progression in vaccine and early treatment era: the COVID-19 Sardinian Progression Score (CSPS)
BackgroundSeveral scores aimed at predicting COVID-19 progression have been proposed. As the variables vaccination and early SARS-CoV-2 treatment...
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Analysis of risk characteristics for early progression and late progression in locally advanced rectal cancer patients: a large population-based and validated study
Background and objectiveThe current study aimed to explore the factors influencing early progression (EP) and late progression (LP) in locally...
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The effect of early remdesivir administration in COVID-19 disease progression in hospitalised patients
BackgroundAntiviral drugs have become crucial in managing COVID-19, reducing complications and mortality. Remdesivir has emerged as an effective...
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Early progression is associated with worse survival in patients with Waldenström’s macroglobulinemia
Early progression of disease within 24 months (POD24) of diagnosis is associated with inferior overall survival (OS) in follicular lymphoma, but its...
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Improved measurement of disease progression in people living with early Parkinson’s disease using digital health technologies
BackgroundDigital health technologies show promise for improving the measurement of Parkinson’s disease in clinical research and trials. However, it...
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Impact of Differential Rates of Disease Progression in Amyloid-Positive Early Alzheimer’s Disease: Findings from a Longitudinal Cohort Analysis
BackgroundThere is limited literature regarding the impact of differential rates of disease progression on longitudinal outcomes in individuals with...
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Potential Implications of Slowing Disease Progression in Amyloid-Positive Early Alzheimer’s Disease: Estimates from Real-World Data
BackgroundEmerging therapies have shown promising results for slowing the progression of Alzheimer’s disease (AD). However, the potential impact of...
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Assessment of COVID-19 lockdown effect on early Alzheimer Disease progression
IntroductionRecently, many aspects of daily life have changed due to the COVID-19 pandemic. Patients with Alzheimer Disease (AD) could be more...
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Different bone health progression patterns and early-stage risk marker in glucocorticoid-treated ambulatory Duchenne muscular dystrophy
SummaryFractures often cause irreversible harm in Duchenne muscular dystrophy (DMD). This study investigated the trajectory of bone mineral density...
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Risk factors for early progression of diffuse low-grade glioma in adults
BackgroundTo explore the risk factors for early progression of diffuse low-grade glioma in adults.
MethodsA retrospective analysis of pathologic and...
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Role of Motivation in the Progression of Problem Gambling: A Comparison of Early and Late Adults
Motivation plays a dominant role in gambling progression. Most studies using motivational scales have revealed that certain motivations are...
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Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease
BackgroundThe clinical course of COVID-19 patients ranges from asymptomatic infection, via mild and moderate illness, to severe disease and even...
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Outcome and risk prediction of early progression in patients with extranodal natural killer/T cell lymphoma from the CLCG study
Recently, progression-free survival at 24 months (PFS24) was defined as clinically relevant for patients with extranodal NK/T cell lymphoma. Herein,...
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Impact of GBA variants on longitudinal freezing of gait progression in early Parkinson’s disease
BackgroundFreezing of gait (FOG) is a common disabling gait disturbance among patients with Parkinson’s disease (PD), but the influence of genetic...
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Progression of varus deformity in osteoarthritic knees induces anterior paradoxical motion of the femur during early knee flexion
PurposeThe purpose of this study was to investigate the position of the femur relative to the tibia throughout range of motion in the osteoarthritic...
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Risk factors of early disease progression and decreased survival for multiple myeloma patients after upfront autologous stem cell transplantation
Multiple myeloma (MM) stands as the second most prevalent hematological malignancy, constituting approximately 10% of all hematological malignancies....
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Early progression of a pancreatic metastasis of synovial sarcoma after pancreatectomy
BackgroundSynovial sarcoma is a malignant tumor that constitutes up to 10% of all soft-tissue sarcomas. The most frequent metastatic sites of...
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DElaying Disease Progression In COPD with Early Initiation of Dual Bronchodilator or Triple Inhaled PharmacoTherapy (DEPICT): A Predictive Modelling Approach
IntroductionClinical studies demonstrate an accelerated decline in lung function in patients with moderate chronic obstructive pulmonary disease...
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Younger age at spinal cord detethering is potentially associated with a reduced risk of curve progression in children with early onset scoliosis
PurposeIn children with early onset scoliosis (EOS) who have tethered spinal cord (TSC), spinal cord detethering is commonly performed prior to...