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Human oocyte area is associated with preimplantation embryo usage and early embryo development: the Rotterdam Periconception Cohort
PurposeTo investigate the association between oocyte area and fertilization rate, embryo usage, and preimplantation embryo development in order to...
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Monomethyl Phthalate Causes Early Embryo Development Delay, Apoptosis, and Energy Metabolism Disruptions Through Inducing Redox Imbalance
Phthalates are a class of environmental endocrine disrupting chemicals which can cause reproductive system damages. However, data about reproductive...
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Influence of COVID-19 infection on early pregnancy outcomes in different periods around frozen embryo transfer
PurposeThe study aimed to investigate the potential influence of COVID-19 infection on embryo implantation and early development in women undergoing...
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A novel machine-learning framework based on early embryo morphokinetics identifies a feature signature associated with blastocyst development
BackgroundArtificial Intelligence entails the application of computer algorithms to the huge and heterogeneous amount of morphodynamic data produced...
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Are Early Embryo Cleavage Kinetics Affected by Energy Substrates in Different Culture Media?
ObjectiveThis study aimed to investigate the influence of different culture media on early embryonic cleavage kinetics using time-lapse analysis and...
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Effect of frozen-thawed embryo transfer with a poor-quality embryo and a good-quality embryo on pregnancy and neonatal outcomes
BackgroundTo evaluate the impact of embryo quality and quantity, specifically a poor quality embryo (PQE) in combination with a good quality embryo...
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Is artificial endometrial preparation more associated with early-onset or late-onset preeclampsia after frozen embryo transfer?
PurposeTo explore whether the risks of early- or late-onset preeclampsia vary among frozen embryo transfer (FET) with different regimens for...
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A novel homozygous mutation in the PADI6 gene causes early embryo arrest
BackgroundIt has been proved that mutations in the PADI6 gene can cause early embryo arrest. This study describes a newly discovered mutation in PADI6 ...
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Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles: Sequential Embryo Transfer or Double-blastocyst Transfer?
ObjectiveBoth sequential embryo transfer (SeET) and double-blastocyst transfer (DBT) can serve as embryo transfer strategies for women with recurrent...
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Embryo Selection for a Carrier of an Early-Onset Alzheimer’s Disease-Associated Mutation in the PSEN1 Gene
Alzheimer’s disease (AD) is the most common neurodegenerative dementia. It manifests as early-onset or late-onset AD. Early-onset AD represents about...
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Early β-hCG levels predict live birth after single embryo transfer
PurposeSpecific serum beta human chorionic gonadotropin (β-hCG) parameters that can predict live birth after an embryo transfer have yet to be...
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Embryo Blastomere Exclusion Identified in a Time-Lapse Culture System Is Associated with Embryo Ploidy
This study examined blastomere exclusion which is seen during embryo development and could represent imperfect cell division or a mechanism of...
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Differential expression of tsRNAs and miRNAs in embryo culture medium: potential impact on embryo implantation
PurposeCan small RNA derived from embryos in conditioned embryo culture medium (ECM) influence embryo implantation?
MethodsWe employed small RNA...
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Determinants of Embryo Implantation: Roles of the Endometrium and Embryo in Implantation Success
Both uterine endometrium and embryo contribute to implantation success. However, their relative role in the implantation success is still a matter...
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MiR-124-3p negatively impacts embryo implantation via suppressing uterine receptivity formation and embryo development
During embryo implantation, blastocyst interacts with the receptivity endometrium and the endometrial epithelium secretes nurturing fluid to support...
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Interleukin-6 Concentration in Single-Embryo Medium Is Associated with Blastocyst Formation
IL-6 plays an important role in oogenesis in humans. However, at the preimplantation stage, IL-6 production and the role in embryo development remain...
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Prediction model for day 3 embryo implantation potential based on metabolites in spent embryo culture medium
BackgroundMetabolites in spent embryo culture medium correlate with the embryo’s viability. However, there is no widely accepted method using...
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Incidence and risk factors for early pregnancy loss in women with first pregnancy undergoing in vitro fertilization-embryo transfer
BackgroundThis study aimed to explore the incidence and influencing factors for early pregnancy loss (EPL) in infertility patients with first...
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Embryo classification beyond pregnancy: early prediction of first trimester miscarriage using machine learning
PurposeFirst trimester miscarriage is a major concern in IVF-ET treatments, accounting for one out of nine clinical pregnancies and for up to one out...
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The Ethics of Stem Cell-Based Embryo-Like Structures
In order to study early human development while avoiding the burdens associated with human embryo research, scientists are redirecting their efforts...