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Mode and site of action of therapies targeting CGRP signaling
Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs...
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Dual-task gait training improves cognition and resting-state functional connectivity in Parkinson’s disease with postural instability and gait disorders
ObjectivesTo assess whether dual-task gait/balance training with action observation training (AOT) and motor imagery (MI) ameliorates cognitive...
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Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
BackgroundEngaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading...
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Flavonoids as dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and in vitro studies
BackgroundInflammation is known to involve in many pathological processes of different diseases, but the current therapy causes adverse effects....
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Dual-modal radiomics nomogram based on contrast-enhanced ultrasound to improve differential diagnostic accuracy and reduce unnecessary biopsy rate in ACR TI-RADS 4–5 thyroid nodules
BackgroundAmerican College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS, TR) 4 and 5 thyroid nodules (TNs) demonstrate much...
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Aclarubicin: contemporary insights into its mechanism of action, toxicity, pharmacokinetics, and clinical standing
Aclarubicin (aclacinomycin A) is one of the anthracycline antineoplastic antibiotics with a multifaceted mechanism of antitumor activity. As a...
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For Better and For Worse: Frequent Gamblers Use Dual Counterfactuals to Justify Continued Gambling
How might frequent gamblers convince themselves to keep playing despite persistent losses or after a win that should be savored? The purpose of this...
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Insights into the potential dual-antibacterial mechanism of Kelisha capsule on Escherichia coli
Traditional Chinese medicine (TCM), AYURVEDA and Indian medicine are essential in disease prevention and treatment. Kelisha capsule ( KLSC ), a TCM...
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A qualitative assessment of multi-sectoral action for non-communicable diseases (NCDs) in Uttar Pradesh, India
IntroductionNon-communicable diseases (NCDs) on the rise globally, especially affecting vulnerable populations in low- and middle-income countries....
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Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption
BackgroundAngiogenesis is regarded as a critical role in bone repair and regeneration, involving in pathological bone disorders such as osteoporosis....
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XGBoost-based multiparameters from dual-energy computed tomography for the differentiation of multiple myeloma of the spine from vertebral osteolytic metastases
ObjectivesTo evaluate the performance of extreme gradient boosting (XGBoost) combined with multiparameters from dual-energy computed tomography...
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Dual inhibition of CPT1A and G6PD suppresses glioblastoma tumorspheres
PurposeLimited treatment options are currently available for glioblastoma (GBM), an extremely lethal type of brain cancer. For a variety of tumor...
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Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs
St. John’s wort is an herb, long used in folk medicine for the treatment of mild depression. Its antidepressant constituent, hyperforin, has...
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The effect of dual-frequency sonication in the presence of thalidomide angiogenesis inhibitor and nanomicelles containing doxorubicin on inhibiting the growth and angiogenesis of breast adenocarcinoma in vivo
This study aimed to evaluate the effect of dual-frequency sonication in the presence of thalidomide angiogenesis inhibitor and nanomicelles...
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Senescence recovering by dual drug-encapsulated liposomal nanoparticles for large-scale human cell expansion
Although regenerative therapy and bioartificial tissues and organs require a sufficient number of human cells, current cell expansion processes are...
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Synergistic action of lactoferrin in enhancing the safety and effectiveness of docetaxel treatment against prostate cancer
BackgroundTumor metastasis is promoted by an immunosuppressive environment. Lactoferrin (Lf) is known to regulate immunological activity in tumor...
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Dual A1 and A2A adenosine receptor antagonists, methoxy substituted 2-benzylidene-1-indanone, suppresses intestinal postprandial glucose and attenuates hyperglycaemia in fructose-streptozotocin diabetic rats
Background/AimRecent research suggests that adenosine receptors (ARs) influence many of the metabolic abnormalities associated with diabetes. A...
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Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia
FLT3 inhibitors (FLT3i) are widely used for the treatment of acute myeloid leukemia (AML), but adaptive and acquired resistance remains a primary...
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Effectiveness and mechanism of action of rTMS combined with quadriceps strength training in individuals with knee osteoarthritis: study protocol for a randomized controlled trial
BackgroundQuadriceps training is necessary in function and activity of daily living for patients with knee osteoarthritis (KOA). However, it did not...
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The dual role of autophagy in acute myeloid leukemia
Acute myeloid leukemia (AML) is a severe hematologic malignancy prevalent in older patients, and the identification of potential therapeutic targets...
