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Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients
ObjectivesThe purpose of this study was to assess the impact of polypharmacy, potentially inappropriate medications, and drug-drug interactions on...
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Enzalutamide: Understanding and Managing Drug Interactions to Improve Patient Safety and Drug Efficacy
Enzalutamide is an oral androgen receptor signaling inhibitor utilized in the treatment of men with prostate cancer. It is a moderate inducer of the...
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Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges
Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug interactions (DDIs) can compromise efficacy and pose serious...
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Signal Detection and Assessment of Herb–Drug Interactions: Saudi Food and Drug Authority Experience
IntroductionNumerous investigations on herbal medicine that have been undertaken in the past several years demonstrate the general acceptance of its...
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Utilising Endogenous Biomarkers in Drug Development to Streamline the Assessment of Drug–Drug Interactions Mediated by Renal Transporters: A Pharmaceutical Industry Perspective
The renal secretion of many drugs is facilitated by membrane transporters, including organic cation transporter 2, multidrug and toxin extrusion...
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Drug–Drug Interactions Involving High-Alert Medications that Lead to Interaction-Associated Symptoms in Pediatric Intensive Care Patients: A Retrospective Study
BackgroundChildren treated in a pediatric intensive care unit (PICU) often receive several drugs together, among them drugs defined as high-alert...
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Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study
BackgroundCardiovascular diseases are responsible for a significant proportion of mortalities worldwide. Elderly patients are the most affected by...
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Anti-coagulant Treatment of Cancer-Associated Thrombosis in Frail Patients: Impact of Frailties on the Management of Drug–Drug Interactions
Low molecular weight heparins (LMWH) and anti-Xa direct oral anti-coagulants (DOACs) are recommended for the long-term treatment of cancer-associated...
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Heart transplantation and human immunodeficiency virus–navigating drug-drug interactions: a case report
BackgroundAntiretroviral therapy (ART) has led to a decline in human immunodeficiency virus (HIV)-related mortality, but comorbidities, including...
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Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information
Many machine learning techniques provide a simple prediction for drug-drug interactions (DDIs). However, a systematically constructed database with...
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Physiologically Based Pharmacokinetic Modeling to Simulate CYP3A4-Mediated Drug-Drug Interactions for Pyrotinib
IntroductionPyrotinib is a newly developed tyrosine kinase inhibitor whose in vivo clearance relies heavily on cytochrome P450 3A4 (CYP3A4) activity....
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Drug–Drug Interactions and the Risk of Emergency Hospitalizations: A Nationwide Population-Based Study
BackgroundSeveral studies suggest a significant risk of hospitalization because of drug–drug interactions in the general population. However, to our...
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Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review
BackgroundGlucagon-like peptide 1 receptor agonists (GLP1RAs) are used in the treatment of diabetes and obesity. Their slowing effect of gastric...
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Development of a Physiologically Based Pharmacokinetic Population Model for Diabetic Patients and its Application to Understand Disease-drug–drug Interactions
IntroductionThe activity changes of cytochrome P450 (CYP450) enzymes, along with the complicated medication scenarios in diabetes mellitus (DM)...
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Pharmacokinetics and pharmacodynamics of drug‒drug interactions in hospitalized older adults treated with direct oral anticoagulants
PurposePolypharmacy is a frequent situation in older adults that increases the risk of drug-drug interactions (DDIs), both pharmacokinetic (PK) and...
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General Framework to Quantitatively Predict Pharmacokinetic Induction Drug–Drug Interactions Using In Vitro Data
IntroductionMetabolic inducers can expose people with polypharmacy to adverse health outcomes. A limited fraction of potential drug–drug interactions...
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Screening for clinically relevant drug-drug interactions between direct oral anticoagulants and antineoplastic agents: a pharmacovigilance approach
BackgroundUse of direct oral anticoagulants (DOACs) in patients with cancer remains suboptimal due to the concern regarding potential drug-drug...
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Potential drug–drug interactions in patients with non-small cell lung cancer at a university hospital in Turkey
BackgroundThe aim of this study was to determine the drug profile of patients with non-small cell lung cancer (NSCLC) and to identify potential...
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Potential drug-drug interactions of immunosuppressants in kidney transplant recipients: comparison of drug interaction resources
Background Drug-drug interactions are frequently observed in kidney transplant recipients due to polypharmacy and use of immunosuppressants. However,...
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Can Mechanistic Static Models for Drug-Drug Interactions Support Regulatory Filing for Study Waivers and Label Recommendations?
Background and ObjectiveMechanistic static and dynamic physiologically based pharmacokinetic models are used in clinical drug development to assess...
