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Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis
Substance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment....
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An Optional Delinked Reward System: Making Pharmaceutical Innovation Work for Everyone
Conflicts over pharmaceutical pricing are driven by the patients’ need for affordable medicines and the producer’s reward for the investments in...
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The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens
Drug addiction therapies commonly fail because continued drug use promotes the release of excessive and pleasurable dopamine levels. Because the...
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Circadian, Reward, and Emotion Systems in Teens prospective longitudinal study: protocol overview of an integrative reward-circadian rhythm model of first onset of bipolar spectrum disorder in adolescence
BackgroundBipolar spectrum disorders (BSDs) are associated with a heightened sensitivity to rewards and elevated reward-related brain function in...
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Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring
It has been previously established that paternal development of a strong incentive motivation for cocaine can predispose offspring to develop high...
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Rats choose alcohol over social reward in an operant choice procedure
The interaction between social factors and alcohol addiction is complex, with potential for both positive and negative contributions to drug use and...
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Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single,...
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Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system
The rostromedial tegmental nucleus (RMTg) plays a crucial role in regulating reward-related behavior by exerting inhibitory control over the ventral...
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Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents
The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied...
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Prenatal exposure to alcohol and its impact on reward processing and substance use in adulthood
Heavy maternal alcohol drinking during pregnancy has been associated with altered neurodevelopment in the child but the effects of low-dose alcohol...
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An appetite for aggressive behavior? Female rats, too, derive reward from winning aggressive interactions
While aggression is an adaptive behavior mostly triggered by competition for resources, it can also in and of itself be rewarding. Based on the...
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Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action
It is well established that dopamine transmission is integral in mediating the influence of reward expectations on reward-seeking actions. However,...
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Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis
BackgroundReward sensitivity constitutes a potential key mechanism regarding the etiology and maintenance of mental disorders, especially depression....
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tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice
DNA cytosine methylation has been documented as a potential epigenetic mechanism of transcriptional regulation underlying opioid use disorder....
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The Sleep-Reward-Pain Pathway Model: an Integrative Review
Purpose of ReviewIn this review, we provide the basis of a mechanistic model, the sleep-reward-pain pathway, which might explain the relationship...
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Early life stress in male mice blunts responsiveness in a translationally-relevant reward task
Early-life stress (ELS) leaves signatures upon the brain that persist throughout the lifespan and increase the risk of psychiatric illnesses...
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Effects of a single dose of amisulpride on functional brain changes during reward- and motivation-related processing using task-based fMRI in healthy subjects and patients with major depressive disorder — study protocol for a randomized clinical trial
BackgroundAnhedonia and other deficits in reward- and motivation-related processing in psychiatric patients, including patients with major depressive...
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Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders
Leading professional health bodies have called for the wider adoption of Patient Reported Outcome Measures, such as quality of life, in research and...
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Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice
Use of the synthetic opioid fentanyl increased ~300% in the last decade, including among women of reproductive ages. Adverse neonatal outcomes and...
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Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking
As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD) treatments could not be more urgent. Two separate...
