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A Dose of Reality About Dose–Response Relationships
Observational research can be strengthened by examining potential dose–response relationships that correlate a clinical intervention with a patient...
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Reduced dose direct oral anticoagulants compared with warfarin with high time in therapeutic range in nonvalvular atrial fibrillation
Direct oral anticoagulants (DOACs) used in nonvalvular atrial fibrillation (NVAF) are dose-reduced in elderly and patients with impaired renal...
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Pharmacological Basis of Differences in Dose Response, Dose Equivalence, and Duration of Action of Inhaled Corticosteroids
IntroductionAsthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are...
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Dose length product to effective dose coefficients in adults
ObjectivesThe most accurate method for estimating patient effective dose (a principal metric for tracking patient radiation exposure) from computed...
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Global impact and cost-effectiveness of one-dose versus two-dose human papillomavirus vaccination schedules: a comparative modelling analysis
BackgroundTo eliminate cervical cancer as a public health problem, the World Health Organization had recommended routine vaccination of adolescent...
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Low Dose Pediatric CT Head Protocol using Iterative Reconstruction Techniques: A Comparison with Standard Dose Protocol
PurposePediatric computed tomography (CT) head examination has also increased in recent years with the advancement in CT technology; however,...
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Dose length product to effective dose coefficients in children
BackgroundThe most accurate method for estimating effective dose (the most widely understood metric for tracking patient radiation exposure) from...
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Inverse planning optimization with lead block effectively suppresses dose to the mandible in high-dose-rate brachytherapy for tongue cancer
PurposeIn this study, we developed in-house software to evaluate the effect of the lead block (LB)-inserted spacer on the mandibular dose in...
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Low-dose versus standard-dose normal temporal bone CT in children: a comparison study
ObjectiveTo compare the image quality of normal anatomical structures and radiation dose on low-dose (LDCT) and standard-dose (SDCT) temporal bone CT...
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Reconsidering pregnancy screening policies for minors: patient-specific estimate of fetus and effective dose for potentially pregnant minors undergoing optimized dose CT of the pelvis
BackgroundOnly verbal pregnancy screening is recommended for post-menarcheal females undergoing pelvic radiographs. In contrast, usually, a...
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75% radiation dose reduction using deep learning reconstruction on low-dose chest CT
ObjectiveFew studies have explored the clinical feasibility of using deep-learning reconstruction to reduce the radiation dose of CT. We aimed to...
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Ultra-low-dose CT for attenuation correction: dose savings and effect on PET quantification for protocols with and without tin filter
BackgroundUltra-low-dose (ULD) computed tomography (CT) scans should be used when CT is performed only for attenuation correction (AC) of positron...
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Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but their dose-effects are unclear. Therefore, we...
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Increased Time in Range with Ultra Rapid Lispro Treatment in Participants with Type 2 Diabetes: PRONTO-Time in Range
IntroductionTo evaluate time in range metrics and HbA1c in people with type 2 diabetes (T2D) treated with ultra rapid lispro (URLi) using continuous...
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Employing Multiple Low-Dose PET Images (at Different Dose Levels) as Prior Knowledge to Predict Standard-Dose PET Images
The existing deep learning-based denoising methods predicting standard-dose PET images (S-PET) from the low-dose versions (L-PET) solely rely on a...
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Novel method for calculating the effective dose using size-specific dose estimates conversion factors in abdomen–pelvis computed tomography
We propose a novel method for calculating the effective dose that closely reflects the individual attenuation, utilizing two conversion coefficients....
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No-Dose Photodynamic Therapy Against Half-Dose Photodynamic Therapy for Treatment of Central Serous Chorioretinopathy
IntroductionThis study aimed to describe the effects of no-dose full-fluence photodynamic therapy without verteporfin (no-dose PDT) and to compare...
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One-year morbidity and mortality in patients treated with standard-dose and low-dose apixaban after acute large vessel occlusion stroke
Although low-dose direct oral anticoagulants (DOACs) are recommended for patients at high risk of bleeding complications, it remains unclear whether...
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Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial
BackgroundMega-dose sodium ascorbate (NaAscorbate) appears beneficial in experimental sepsis. However, its physiological effects in patients with...
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Low-iodine-dose computed tomography coupled with an artificial intelligence-based contrast-boosting technique in children: a retrospective study on comparison with conventional-iodine-dose computed tomography
BackgroundLow-iodine-dose computed tomography (CT) protocols have emerged to mitigate the risks associated with contrast injection, often resulting...
