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A Dose of Reality About Dose–Response Relationships
Observational research can be strengthened by examining potential dose–response relationships that correlate a clinical intervention with a patient...
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Pharmacological Basis of Differences in Dose Response, Dose Equivalence, and Duration of Action of Inhaled Corticosteroids
IntroductionAsthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are...
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Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but their dose-effects are unclear. Therefore, we...
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Dose-response relationships of LSD-induced subjective experiences in humans
Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. Here...
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A case of squamous cell carcinoma of the breast achieved a pathological complete response after dose-dense AC + dose-dense PTX
BackgroundSquamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is...
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Associations of obesity indices change with cardiovascular outcomes: a dose-response meta-analysis
BackgroundLittle is known about the degrees and shapes of associations of changes in obesity indices with cardiovascular disease (CVD) and mortality...
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Low-Dose Radiation Yields Lower Rates of Pathologic Response in Esophageal Cancer Patients
BackgroundAlthough neoadjuvant chemoradiation (nCRT) followed by surgery is standard treatment for locally advanced esophageal or gastroesophageal...
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The Best Exercise Modality and Dose to Reduce Glycosylated Hemoglobin in Patients with Type 2 Diabetes: A Systematic Review with Pairwise, Network, and Dose–Response Meta-Analyses
BackgroundPersistently elevated glycosylated hemoglobin (HbA1c) is associated with a higher risk of long-term vascular complications.
Objective ...
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Association between obstructive sleep apnea severity and depression risk: a systematic review and dose-response meta-analysis
Obstructive sleep apnea (OSA) has received considerable attention as a potential risk factor for depressive symptoms. The systematic review was...
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Association of parathyroid hormone with risk of hypertension and type 2 diabetes: a dose-response meta-analysis
BackgroundDespite an increase in parathyroid hormone (PTH) has been reported to be associated with a higher risk of hypertension and type 2 diabetes...
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Dose-response association of obesity and risk of mental health among tehranian residents: result of a cross-sectional study
BackgroundObesity and mental health issues are two of the most prevalent global public health issues for a significant portion of people. The purpose...
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A flexible dose-response modeling framework based on continuous toxicity outcomes in phase I cancer clinical trials
BackgroundThe past few decades have seen remarkable developments in dose-finding designs for phase I cancer clinical trials. While many of these...
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A Prospective Open-Label Dose–Response Study to Correct Vitamin D Deficiency in Cirrhosis
BackgroundPatients with advanced liver disease often have vitamin D deficiency, but the daily dosages of vitamin D 3 needed to raise their serum...
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Population Pharmacodynamic Dose–Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate
BackgroundSodium zirconium cyclosilicate (SZC) is an approved oral treatment for hyperkalemia that selectively binds potassium (K + ) in the...
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Biphasic dose response in the anti-inflammation experiment of PBM
Non-invasive laser irradiation can induce photobiomodulation (PBM) effects in cells and tissues, which can help reduce inflammation and pain in...
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Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial
BackgroundLaryngeal mask airway(LMA) have been widely used in clinical practice. Irritation to the patient during the insertion of a laryngeal mask...
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Dose–response relationship between active smoking and lung cancer mortality/prevalence in the Chinese population: a meta-analysis
BackgroundThe dose‒response relationship-based relative risk (RR) of smoking exposure could better predict the risk of lung cancer than the...
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Physical activity during pregnancy and the risk of gestational diabetes mellitus: a systematic review and dose–response meta-analysis
BackgroundPrevious research has indicated the inverse association between physical activity (PA) and gestational diabetes mellitus (GDM). However,...
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Nomogram to predict FSH starting dose in poor ovarian response women in progestin primed ovarian stimulation protocol
Prediction of individual ovarian response to exogenous gonadotropin is a cornerstone for success and safety in all controlled ovarian stimulation...
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Use of dose–volume histograms for metabolic response prediction in hepatocellular carcinoma patients undergoing transarterial radioembolization with Y-90 resin microspheres
IntroductionVoxel-based dosimetry offers improved outcomes in the treatment of hepatocellular carcinoma (HCC) with transarterial radioembolization...
