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Usefulness of an S-1 dosage formula: an exploratory analysis of randomized clinical trial (JCOG1001)
BackgroundThe blood concentration of S-1 and adverse events are affected by renal function. Herein, an S-1 dosage formula was developed based on...
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Evaluation of clinical validity of an S-1 dosage formula based on renal function using data of the SPIRITS and the G-SOX trials
BackgroundThe aim of this study was to evaluate clinical validity of the S-1 dosage formula based on body surface area (BSA) and creatinine clearance...
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Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice
BackgroundBushenhuoxue (BSHX) formula, a ten-compound herbal decoction, is widely used to treat postmenopausal osteoporosis (PMOP) in China. However,...
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Safety and efficacy of adding postbiotics in infant formula: a systematic review and meta-analysis
AbstractPostbiotics, as emerging products, were added to infant formula, but their safety and efficacy are unclear. To clarify this issue, we wrote...
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Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol
BackgroundPrediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a...
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Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine
BackgroundTraditional Chinese medicine (TCM) has been used to treat various diseases for thousands of years. However, the uncertainty of dosage as...
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Different glomerular filtration rate estimating formula for prescribing DOACs in oldest patients: appropriate dosage and bleeding risk. Post hoc analysis of a prospective cohort
BackgroundDirect oral anticoagulants (DOACs) pharmacokinetics depends on estimated glomerular filtration rate (eGFR), whose estimation is crucial for...
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Dose Nomogram of Individualization of the Initial Follicle-Stimulating Hormone Dosage for Patients with Polycystic Ovary Syndrome Undergoing IVF/ICSI with the GnRH-Ant Protocol: A Retrospective Cohort Study
IntroductionFor high responders with polycystic ovary syndrome (PCOS), there is no clear recommendation for the initial follicle-stimulating hormone...
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Improvement effects of a novel Chinese herbal formula in imiquimod and IL-23-stimulated mouse models of psoriasis
BackgroundPsoriasis is a long-term inflammatory skin disease. A novel herbal formula containing nine Chinese herbal medicines, named Inflammation...
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Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study
Genomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug...
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Toxicity and toxicokinetics of the ethanol extract of Zuo** formula
BackgroundZuo** formula, a traditional Chinese medicine, comprises Coptis chinensis and Evodia rutaecarpa . In our previous study, the total...
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VIVEX: A Formula for Calculating Individual Vitreous Volume: A New Approach Towards Tailored Patient Dosing Regime in Intravitreal Therapy
IntroductionPersonalized medicine and patient-tailored drug dosing have been substantiated through thousands of clinical studies, demonstrating their...
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Combined and comparative analytical studies with stability studies and validation for estimation of prenoxdiazine HCl in pharmaceutical dosage form
BackgroundA precise, accurate, economical and reproducible UV, RP-HPLC and UPLC method has been developed for the estimation of Prenoxdiazine...
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A novel strategy for optimal component formula of anti-PRRSV from natural compounds using tandem mass tag labeled proteomic analyses
BackgroundPorcine Reproductive and Respiratory Syndrome (PRRS) is one of the most important porcine viral diseases which have been threatening the...
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Wenyang Huazhuo Tongluo formula alleviates pulmonary vascular injury and downregulates HIF-1α in bleomycin-induced systemic sclerosis mouse model
BackgroundVascular damage, autoimmune abnormalities, and fibrosis are the three pathological features of systemic sclerosis (SSc).However, pulmonary...
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Treg Immunomodulation Contributes to the Anti-atherosclerotic Effects of Huxin Formula in ApoE-/- Mice
ObjectiveTo explore the effects of Huxin formula (HXF) in curtailing atherosclerosis and its underlying mechanism.
MethodsAccording to random number...
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Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat
BackgroundNon-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD) for which there is yet any standard...
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Formulation, optimization, qualitative and quantitative analysis of new dosage form of corticosteroid
BackgroundThe objective of the present research work is to develop the entirely new drug product formulation (Ophthalmic Suspension) which belongs to...
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Determination of Optimal Vitamin D Dosage in Children with Cholestasis
BackgroundVitamin D deficiency in patients with cholestasis is due to impaired intestinal vitamin D absorption, which results from decreased...
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LMWHs dosage and outcomes in acute pulmonary embolism with renal insufficiency, an analysis from a large real-world study
BackgroundRenal function is associated with prognoses for acute pulmonary embolism (PE).
ObjectiveTo investigate the application of anticoagulants...
