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Study on the mechanism of P2X receptors involved in electroacupuncture treatment of neuropathic pain in dorsal root ganglion and spinal cord
Neuropathic pain (NP) is directly caused by lesions or diseases of the somatosensory system. It can be attributed to a variety of causes and has a...
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Effects of Photodynamic Therapy on Nav1.7 Expression in Spinal Dorsal Root Ganglion Neurons
ObjectiveThe aim of this study was to examine the effects of photodynamic therapy (PDT) on the expression of Nav1.7 in spinal dorsal root ganglion...
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Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons
BackgroundJanus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that...
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Efficacy of conditioned autologous serum therapy (Orthokine®) on the dorsal root ganglion in patients with chronic radiculalgia: study protocol for a prospective randomized placebo-controlled double-blind clinical trial (RADISAC trial)
BackgroundPulsed radiofrequency (PRF) treatment on the dorsal root ganglion (DRG) has been proposed as a good option for the treatment of persistent...
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Dorsal Root Ganglion Morphometric Changes Under Oxaliplatin Treatment
PurposeMagnetic resonance neurography (MRN) can detect dorsal root ganglia (DRG) hypertrophy in patients with oxaliplatin-induced peripheral...
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Dorsal root entry zone lesioning for brachial plexus avulsion - technical evolution and long-term follow-up
BackgroundBrachial plexus avulsion (BPA) injuries can cause severe deafferentation pain. This has been successfully treated with dorsal root entry...
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Efficacy and safety of pulsed radiofrequency modulation of thoracic dorsal root ganglion or intercostal nerve on postherpetic neuralgia in aged patients: a retrospective study
BackgroundPostherpetic neuralgia (PHN) is common in elderly patients and can be alleviated by pulsed radiofrequency (PRF). However, PRF treatments...
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The role of periradicular infiltration in dorsal root ganglion stimulation for chronic neuropathic pain
BackgroundTargeting the correct spinal level is essential in dorsal root ganglion (DRG) stimulation. Anatomical selection of the DRG alone is not...
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Comparing the effects of current circumcision techniques on dorsal root ganglia: an experimental study
BackgroundCircumcision is a surgical removal process of the preputium. Surgical excision and electric current cause neurodegeneration in the excised...
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Dorsal root ganglia: fibromyalgia pain factory?
This perspective article focuses on dorsal root ganglia (DRG) as potential fibromyalgia main pain source. Humans possess 31 pairs of DRG lying along...
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Successful neurolytic thoracic sympathetic ganglion block using C-arm fluoroscopic cone-beam computed tomography in patients with postmastectomy pain syndrome: a report of 3 cases
BackgroundPostmastectomy pain syndrome involves persistent neuropathic and sympathetically maintained neuropathic pain that can be improved using a...
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Hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells are involved in overactive bladder syndrome in rats
BackgroundTo investigate the functions of the hyperpolarization-activated cation currents in medium-size dorsal root ganglion cells in a rat model of...
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Lipopolysaccharide-induced Trigeminal Ganglion Nerve Fiber Damage is Associated with Autophagy Inhibition
ObjectiveThis study aimed to determine whether lipopolysaccharide (LPS) induces the loss of corneal nerve fibers in cultured trigeminal ganglion (TG)...
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Effects of Hirudin on High Glucose-Induced Oxidative Stress and Inflammatory Pathway in Rat Dorsal Root Ganglion Neurons
ObjectiveTo investigate protective effects of hirudin on oxidative stress and apoptosis of spinal dorsal root ganglion cells in high-glucose rats at...
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Intrathecal gastrodin alleviates allodynia in a rat spinal nerve ligation model through NLRP3 inflammasome inhibition
BackgroundGastrodin (GAS), a main bioactive component of the herbal plant, Gastrodia elata Blume, has shown to have beneficial effects on...
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Effects of preventative moxibustion at Shenque (CV8) and Guanyuan (CV4) on BDNF-TrkB pathway in the spinal dorsal horn and hypothalamus in rats with dysmenorrhea
ObjectiveTo observe the effects of preventative moxibustion on analgesia, substance P (SP), prostaglandin (PG) F 2α and PGE 2 in rats with...
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LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion
BackgroundTrigeminal nerve injury is one of the most serious complications in oral clinics, and the subsequent chronic orofacial pain is a...
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Exploring the effect of Tuina on the dendritic structure of spinal cord dorsal horn in rats with lumbar disc herniation based on NR2B/PSD-95 pathway
ObjectiveTo investigate the analgesic mechanism of Tuina (Chinese therapeutic massage) by observing the effect of the N-methyl-D-aspartate receptor...
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Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors
BackgroundTrace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the...
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Analysis of Efficacy and Factors Associated with Reccurence After Radiofrequency Thermocoagulation in Patients with Postherpetic Neuralgia: a Long-Term Retrospective and Clinical Follow-Up Study
IntroductionPostherpetic neuralgia (PHN) is a painful condition that persists for 1 month or more after herpes zoster rash has healed. Radiofrequency...
