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Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors
The pathology of depression is related to the imbalance of various neurotransmitters. The dorsal raphe nucleus (DRN), the main brain region producing...
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High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats
Drug addiction represents a multifaceted and recurrent brain disorder that possesses the capability to create persistent and ineradicable...
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Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway
Serotonin 2C receptors (5-HT2CRs) are widely distributed throughout the brain and are strongly implicated in the pathophysiology of anxiety disorders...
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LC-derived excitatory synaptic transmission to dorsal raphe serotonin neurons is inhibited by activation of alpha2-adrenergic receptors
In the central nervous system, noradrenaline transmission controls the degree to which we are awake, alert, and attentive. Aberrant noradrenaline...
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Dorsal raphe to basolateral amygdala corticotropin-releasing factor circuit regulates cocaine-memory reconsolidation
Environmental stimuli elicit drug craving and relapse in cocaine users by triggering the retrieval of strong cocaine-related contextual memories....
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Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice
Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This...
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Associated factors and abnormal dorsal raphe nucleus connectivity patterns of freezing of gait in Parkinson’s disease
BackgroundFreezing of gait (FOG) is a common, disabling symptom of Parkinson’s disease (PD), and its exact pathophysiological mechanism is still...
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Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats
Mood disorders, including anxiety and depression caused by prenatal ethanol exposure (PE) are prevalent conditions in fetal alcohol spectrum...
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Methylphenidate induces a different response in the dorsal raphe as compared to ventral tegmental area and locus coeruleus: behavioral and concomitant neuronal recordings in adult rats
Methylphenidate (MPD) is a psychostimulant used to treat attention deficit hyperactivity disorder. MPD exerts its neurocognitive effects through...
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Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors
Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain....
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Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression
Heightened aggressive behavior is considered as one of the central symptoms of many neuropsychiatric disorders including autism, schizophrenia, and...
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Divergent modulation of pain and anxiety by GABAergic neurons in the ventrolateral periaqueductal gray and dorsal raphe
The ventrolateral periaqueductal gray (vlPAG) collaborates with the dorsal raphe (DR) in pain regulation and emotional response. However, the roles...
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Dorsal peduncular cortex activity modulates affective behavior and fear extinction in mice
The medial prefrontal cortex (mPFC) is critical to cognitive and emotional function and underlies many neuropsychiatric disorders, including mood,...
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Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson’s disease with chronic pain
Background and ObjectiveThere are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson’s disease (PD). In the...
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Role of raphe magnus 5-HT1A receptor in increased ventilatory responses induced by intermittent hypoxia in rats
BackgroundIntermittent hypoxia induces increased ventilatory responses in a 5-HT-dependent manner. This study aimed to explore that effect of raphe...
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STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology
The signal transducer and activator of transcription 3 (STAT3) signalling pathway is activated through phosphorylation by Janus kinases in response...
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The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus
The ependymal epithelium forms the cerebrospinal fluid barrier, separating the brain and spinal cord from the cerebrospinal fluid. However, in...
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High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin
Serotonergic psychedelics are emerging therapeutics for psychiatric disorders, yet their underlying mechanisms of action in the brain remain largely...
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ErbB4 knockdown in serotonergic neurons in the dorsal raphe induces anxiety-like behaviors
There is a close relationship between serotonergic (5-HT) activity and anxiety. ErbB4, a receptor tyrosine kinase, is expressed in 5-HT neurons....
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Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice
Serotonin (5-HT)-based antidepressants, selective serotonin reuptake inhibitors (SSRIs) aim to enhance serotonergic activity by blocking its...
