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Detection of novel PPP1R1B::STARD3 fusion transcript in acute myeloid leukemia: a case report
BackgroundAcute myeloid leukemia (AML) is the second most common type of leukemia in children. Although prognostic and diagnostic tests of AML...
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The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment
The stimulant methylphenidate (MPH) and the non-stimulant atomoxetine (ATX) are frequently used for the treatment of attention-deficit/hyperactivity...
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Pathological mechanisms and treatment of sporadic Parkinson’s disease: past, present, and future
For a special issue, we review studies on the pathogenesis of nigral cell death and the treatment of sporadic Parkinson’s disease (sPD) over the past...
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Shedding a new light on Huntington’s disease: how blood can both propagate and ameliorate disease pathology
Huntington’s disease (HD) is a monogenic neurodegenerative disorder resulting from a mutation in the huntingtin gene. This leads to the expression of...
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An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
Alternative splicing of schizophrenia risk genes, such as DRD2 , GRM3 , and DISC1 , has been extensively described. Nevertheless, the alternative...
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Targeting β-Arrestins in the Treatment of Psychiatric and Neurological Disorders
Therapies for psychiatric and neurological disorders have been in the development and refinement process for the past 5 decades. Yet, most of these...
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Promise and challenges of dystonia brain banking: establishing a human tissue repository for studies of X-Linked Dystonia-Parkinsonism
X-Linked Dystonia-Parkinsonism (XDP) is a neurodegenerative disease affecting individuals with ancestry to the island of Panay in the Philippines. In...
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Amantadine: reappraisal of the timeless diamond—target updates and novel therapeutic potentials
The aim of the current review was to provide a new, in-depth insight into possible pharmacological targets of amantadine to pave the way to extending...
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Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation
Infectious or noninfectious maternal immune activation (MIA) is an environmental risk factor for psychiatric and neurological disorders with...
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Dopaminergic modulation of striatal function and Parkinson’s disease
The striatum is richly innervated by mesencephalic dopaminergic neurons that modulate a diverse array of cellular and synaptic functions that control...
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Signal transduction in l-DOPA-induced dyskinesia: from receptor sensitization to abnormal gene expression
A large number of signaling abnormalities have been implicated in the emergence and expression of l -DOPA-induced dyskinesia (LID). The primary cause...
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Opiate-associated contextual memory formation and retrieval are differentially modulated by dopamine D1 and D2 signaling in hippocampal–prefrontal connectivity
Contextual memory driven by abused drugs such as opiates has a central role in maintenance and relapse of drug-taking behaviors. Although dopamine...
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Dopamine receptors: homomeric and heteromeric complexes in l-DOPA-induced dyskinesia
The current standard treatment for Parkinson disease focuses on restoring striatal dopamine levels using l -3,4-dihydroxyphenylalanine ( l -DOPA)....
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CK1δ over-expressing mice display ADHD-like behaviors, frontostriatal neuronal abnormalities and altered expressions of ADHD-candidate genes
The cognitive mechanisms underlying attention-deficit hyperactivity disorder (ADHD), a highly heritable disorder with an array of candidate genes and...
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Identification of important invasion and proliferation related genes in adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is an end‐stage hormonal syndrome. Although profound attempts have been made to illuminate the pathogenesis, the...
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Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic–Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement
Appetitive drive is influenced by coordinated interactions between brain circuits that regulate reinforcement and homeostatic signals that control...
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Postsynaptic movement disorders: clinical phenotypes, genotypes, and disease mechanisms
Movement disorders comprise a group of heterogeneous diseases with often complex clinical phenotypes. Overlap** symptoms and a lack of diagnostic...
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Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis
BackgroundAdult height is associated with risk of several diseases, but the breadth of such associations and whether these associations are primary...
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Synaptic plasticity and levodopa-induced dyskinesia: electrophysiological and structural abnormalities
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons located in the midbrain....
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Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update—I. Hypokinetic-rigid movement disorders
Extrapyramidal movement disorders include hypokinetic rigid and hyperkinetic or mixed forms, most of them originating from dysfunction of the basal...
