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Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice
Impulsive choice, often characterized by excessive preference for small, short-term rewards over larger, long-term rewards, is a prominent feature of...
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Social interaction-induced fear memory reduction: exploring the influence of dopamine and oxytocin receptors on memory updating
It has been well established that a consolidated memory can be updated during the plastic state induced by reactivation. This updating process opens...
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Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT3 and Dopamine D2 Receptors in Mice
Background/AimsWe examined the contributions of gastric emptying and duodenogastric bile reflux in the formation of gastric antral ulcers induced by...
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Brain connectivity changes to fast versus slow dopamine increases
The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on how fast they raise dopamine in the brain. Yet how the rate...
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Effects of anesthetics on expression of dopamine and acetylcholine receptors in the rat brain in vivo
Dopamine D 2 and acetylcholine M 1 receptors might be related to post-operative cognitive dysfunction. The aim of the present study is to investigate...
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Role of dopamine agonists in Parkinson's disease therapy
Dopamine agonists are an important component of Parkinson's therapy. When weighing up the various therapy options, therapy with levodopa has recently...
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Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine
The catecholamine neuromodulators dopamine and norepinephrine are implicated in motor function, motivation, and cognition. Although roles for...
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PET imaging of dopamine transporters and D2/D3 receptors in female monkeys: effects of chronic cocaine self-administration
Brain imaging studies using positron emission tomography (PET) have shown that long-term cocaine use is associated with lower levels of dopamine (DA)...
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Seasonal variation in D2/3 dopamine receptor availability in the human brain
PurposeBrain functional and physiological plasticity is essential to combat dynamic environmental challenges. The rhythmic dopamine signaling...
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Subcutaneous adipose tissue dopamine D2 receptor is increased in prediabetes and T2D
PurposeTo evaluate the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and potential direct...
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Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression
Sensitive developmental periods shape neural circuits and enable adaptation. However, they also engender vulnerability to factors that can perturb...
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PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors that regulate gene expression. Δ 9 -tetrahydrocannabinol (Δ 9 -THC)...
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Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning
Cholinergic interneurons (CINs) in the striatum respond to salient stimuli with a multiphasic response, including a pause, in neuronal activity....
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The effect of selective nigrostriatal dopamine excess on behaviors linked to the cognitive and negative symptoms of schizophrenia
Excess dopamine release in the dorsal striatum (DS) is linked to psychosis. Antipsychotics are thought to work by blocking striatal D2 dopamine...
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Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia
The brain neurotramsmitter dopamine may play an important role in modulating systemic glucose homeostasis. In seven hundred and four drug- naïve...
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Long-term alcohol consumption alters dorsal striatal dopamine release and regulation by D2 dopamine receptors in rhesus macaques
The dorsal striatum (DS) is implicated in behavioral and neural processes including action control and reinforcement. Alcohol alters these processes...
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cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement
Chronic cocaine exposure induces enduring neuroadaptations that facilitate motivated drug taking. Hyperpolarization-activated cyclic nucleotide-gated...
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The role of neurotransmitter receptors in antipsychotic medication efficacy for Alzheimer’s-related psychosis
BackgroundAlzheimer's disease (AD) is marked by cognitive decline along with the presence of mental symptoms, most notably psychosis. Although...
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Nicotinic receptors promote susceptibility to social stress in female mice linked with neuroadaptations within VTA dopamine neurons
There are about twice as many women as men who experience depression during their lifetime. Although life circumstances and especially exposure to...
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Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies
The dopamine hypothesis of schizophrenia posits that elevated striatal dopamine functioning underlies the development of psychotic symptoms. Chronic...
