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Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Trace amine-associated receptor 1 (TAAR1) is an intracellular expressed G-protein-coupled receptor that is widely expressed in major dopaminergic...
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Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking
The transition from hedonic alcohol drinking to problematic drinking is a hallmark of alcohol use disorder that occurs only in a subset of drinkers....
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Subcutaneous adipose tissue dopamine D2 receptor is increased in prediabetes and T2D
PurposeTo evaluate the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and potential direct...
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Seasonal variation in D2/3 dopamine receptor availability in the human brain
PurposeBrain functional and physiological plasticity is essential to combat dynamic environmental challenges. The rhythmic dopamine signaling...
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D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum
Dopamine (DA) acts as a key regulator in controlling emotion, and dysfunction of DA signal has been implicated in the pathophysiology of some...
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Brain connectivity changes to fast versus slow dopamine increases
The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on how fast they raise dopamine in the brain. Yet how the rate...
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Chronic treatment with D2-antagonist haloperidol leads to inhibitory/excitatory imbalance in striatal D1-neurons
Striatal dysfunction has been implicated in the pathophysiology of schizophrenia, a disorder characterized by positive symptoms such as...
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Dopamine Receptor Expression and the Pathogenesis of Attention-Deficit Hyperactivity Disorder: a Sco** Review of the Literature
Purpose of ReviewCNS stimulants have been the treatment of choice among children with attention-deficit hyperactivity disorder (ADHD) ages 6 and...
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Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome
Polycystic ovarian syndrome (PCOS) is a disorder with a foundation of neuroendocrine dysfunction, characterized by increased gonadotropin-releasing...
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Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine
BackgroundThe pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors...
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Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
A two-neuron model of ventral tegmental area (VTA) opioid function classically involves VTA GABA neuron regulation of VTA dopamine neurons via a mu -op...
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Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex
The ventromedial prefrontal cortex (vmPFC; rodent infralimbic cortex (IL)), is posited to be an important locus of fear extinction-facilitating...
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Role of dopamine agonists in Parkinson's disease therapy
Dopamine agonists are an important component of Parkinson's therapy. When weighing up the various therapy options, therapy with levodopa has recently...
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Disentangling the role of NAc D1 and D2 cells in hedonic eating
Overeating is driven by both the hedonic component (‘liking’) of food, and the motivation (‘wanting’) to eat it. The nucleus accumbens (NAc) is a key...
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Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia
The brain neurotramsmitter dopamine may play an important role in modulating systemic glucose homeostasis. In seven hundred and four drug- naïve...
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Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats
Stress-linked disorders are more prevalent in women than in men and differ in their clinical presentation. Thus, investigating sex differences in...
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Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus
BackgroundPrefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes,...
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Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression
Sensitive developmental periods shape neural circuits and enable adaptation. However, they also engender vulnerability to factors that can perturb...
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Dopamine D2 receptor on CD4+ T cells is protective against inflammatory responses and signs in a mouse model of rheumatoid arthritis
BackgroundDopamine is a neurotransmitter and has been found to regulate lymphocytes by acting on dopamine receptors (DRs). CD4 + T cells express all...
