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Lithium-discontinuation-induced treatment refractoriness revisited
BackgroundLithium is effective in the long-term treatment of bipolar disorder. Concerns have been raised about non-responsiveness after...
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Rebound activation of 5-HT neurons following SSRI discontinuation
Cessation of therapy with a selective serotonin (5-HT) reuptake inhibitor (SSRI) is often associated with an early onset and disabling...
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Disentangling pharmacological and expectation effects in antidepressant discontinuation among patients with fully remitted major depressive disorder: study protocol of a randomized, open-hidden discontinuation trial
BackgroundAntidepressants are established as an evidence-based, guideline-recommended treatment for Major Depressive Disorder. Prescriptions have...
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Denosumab Discontinuation
Purpose of ReviewTo review the pathophysiology, the clinical consequences as well as way of mitigating the effects of denosumab discontinuation.
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Discontinuation of psychotropic medication: a synthesis of evidence across medication classes
Pharmacotherapy is an effective treatment modality across psychiatric disorders. Nevertheless, many patients discontinue their medication at some...
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Discontinuation and nonpublication of clinical trials in orthopaedic oncology
BackgroundDespite the pivotal role of clinical trials in advancing orthopaedic oncology knowledge and treatment strategies, the persistent issues of...
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Long–Term Outcome After Discontinuation of CGRP-Targeting Therapy for Migraine
Purpose of reviewCalcitonin gene-related peptide (CGRP)-targeting agents are potential candidates for disease-modifying migraine drugs. However, most...
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Factors associated with discontinuation in fertility treatment: a systematic sco** review
PurposeThe discontinuation of fertility treatment could decrease the chances of achieving parenthood for infertile patients and often leads to...
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Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants
BackgroundFactors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the...
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Predictors of contraceptive discontinuation in Rwanda: evidence from demographic and health survey 2019–2020
BackgroundDespite advancements, Rwanda continues to face challenges regarding contraceptive discontinuation. The 2019–2020 Rwanda Demographic and...
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Exploring the prevalence of antidepressant medication discontinuation among pregnant veterans
US female veterans have higher rates of mental health (MH) disorders compared to US civilian females and, consequently, are at risk for poor MH...
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Remdesivir Discontinuation Decisions Based on Thresholds of Aminotransferase in an Observational Registry
BackgroundRemdesivir is an antiviral approved by the US Food and Drug Administration (FDA) for treatment of coronavirus disease 2019 (COVID-19), and...
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Association between prognostic nutritional index and peritoneal dialysis discontinuation: a retrospective cohort study
BackgroundMalnutrition is associated with discontinuing peritoneal dialysis (PD). The prognostic nutritional index (PNI), composed of serum albumin...
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Feasibility and safety of the discontinuation of systemic immunosuppressive treatment after single-unit cord blood transplantation in adults
We retrospectively evaluated the incidence, factors, and clinical outcomes of the discontinuation of immunosuppressive treatment (IST) after...
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Postoperative use and early discontinuation of intravenous lidocaine in spine patients
PurposeOur institution employs a multimodal approach to manage postoperative pain after spine surgery. It involves continuous intravenous (IV)...
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Treatment setting and buprenorphine discontinuation: an analysis of multi-state insurance claims
BackgroundPotential differences in buprenorphine treatment outcomes across various treatment settings are poorly characterized in multi-state...
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Factors associated with early discontinuation of anamorelin in patients with cancer-associated cachexia
PurposeCancer-associated cachexia, a multifactorial syndrome involving loss of muscle mass and anorexia, is an unremitting problem for cancer...
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Peritoneal dialysis discontinuation: to the root of the problem
As the global burden of chronic kidney disease continues to increase, the use of peritoneal dialysis is often advocated as the preferred initial...
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Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation
Background/PurposeLittle is known about long-term clinical outcomes or urate-lowering (ULT) therapy use following pegloticase discontinuation. We...
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Patient characteristics and reasons for discontinuation in a cardiovascular risk management programme in The Netherlands
BackgroundSince 2010, an increasing number of patients have participated in a nurse-led integrated cardiovascular risk management programme in the...
