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Evaluation of clinical outcomes in patients treated with heparin or direct thrombin inhibitors during extracorporeal membrane oxygenation: a systematic review and meta-analysis
BackgroundThe number of patients treated with extracorporeal membrane oxygenation (ECMO) devices is increasing. Anticoagulation therapy is crucial to...
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Direct Oral Anticoagulants: An Update on Monitoring and Antidotes for the Perioperative Physician
Purpose of ReviewThe purpose of this review is to update the clinician on assessing and reversing the effects of direct oral anticoagulants (DOACs)...
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Evaluation of direct thrombin inhibitors during a critical heparin shortage
A recent heparin shortage related to an outbreak of African Swine Flu in China led to substantial increase in the use of direct thrombin inhibitors...
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Profibrinolytic effects of rivaroxaban are mediated by thrombin-activatable fibrinolysis inhibitor and are attenuated by a naturally occurring stabilizing mutation in enzyme
Rivaroxaban is a direct factor Xa inhibitor, recently implemented as a favorable alternative to warfarin in anticoagulation therapy. Rivaroxaban...
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Ultrasound (US)-guided percutaneous thrombin injection for stoma-site bleeding after PEG tube insertion: a case series and review of the literature
BackgroundPost-gastrostomy bleeding sequelae are acknowledged, with reported approaches focusing on conservative measures or surgical repair....
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Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis
We explored the effect of thrombin on human aortic smooth muscle cells (HASMCs) and further analyzed its role in the pathogenesis of atherosclerosis...
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Do Oral Factor Xa Inhibitors have a Role in Patients with Mechanical Heart Valves?
Mechanical heart valves (MHVs) replacement is recommended for younger patients with valvular heart disease because of the durability of the...
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Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives
Purpose of the ReviewThrombotic risk assessment in antiphospholipid positive (aPL +) subjects is a major challenge, and the study of in vitro...
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Calibrated automated thrombogram II: removing barriers for thrombin generation measurements
BackgroundThrombin generation (TG) assessed by Calibrated Automated Thrombogram (CAT-I) reflects the overall capacity of plasma to generate thrombin,...
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Enhanced thrombin generation detected with ST-Genesia analyzer in patients with newly diagnosed multiple myeloma
The issue of how to identify newly diagnosed multiple myeloma (NDMM) patients requiring thromboprophylaxis remains unsolved. Several changes in...
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Development and validation of an analytical method for the determination of direct oral anticoagulants (DOAC) and the direct thrombin-inhibitor argatroban by HPLC–MS/MS
Since direct oral anticoagulants (DOAC) are administered frequently to an elderly, co-morbid population, medical emergencies including trauma, acute...
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Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background
BackgroundThe current study aims to identify the relationships between coagulation factors and plasma thrombin generation in a large population-based...
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Factor XI Inhibitors: A New Horizon in Anticoagulation Therapy
Anticoagulation therapy has undergone significant evolution, marked by the emergence of direct oral anticoagulants with distinct advantages. Despite...
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When and How to Use Reversal Agents for Direct Oral Anticoagulants?
Purpose of ReviewOur objective is to describe currently available reversal agents for direct oral anticoagulants (DOACs), their target population,...
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Potential Therapeutic Roles for Direct Factor Xa Inhibitors in Coronavirus Infections
Human factor Xa (FXa) is a serine protease of the common coagulation pathway. FXa is known to activate prothrombin to thrombin, which eventually...
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Thrombin Generation in Trauma Patients: How Do we Navigate Through Scylla and Charybdis?
Purpose of ReviewCoagulopathy is a complex pathological condition manifested through the insufficient or excessive tendency to form blood thrombi,...
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Modified thromboelastometric tests provide improved sensitivity and specificity to direct oral anticoagulants compared to standard thromboelastometric tests in-vitro
BackgroundThe detection of direct oral anticoagulants (DOACs) is still challenging but important in emergency patients. We recently demonstrated that...
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Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15
G-protein coupled receptor 15 (GPR15) is expressed on T-cells. We previously reported knockout of GPR15 increased acute graft- versus -host disease (G v H...
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Factor Xa inhibitors versus vitamin K antagonist in morbidly obese patients with venous thromboembolism: a systematic review and meta-analysis
IntroductionGuidelines have endorsed non-vitamin K antagonist oral anticoagulants (NOACs), consisting of factor Xa inhibitors (xabans) and direct...
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Factor XI Inhibitors: perspectives in primary and secondary prevention of ischemic stroke
Stroke is one of the most common causes of mortality and disability worldwide. Antithrombotic therapy represents the mainstay in primary and...
