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Diagnostic value of routine blood tests in differentiating between SARS-CoV-2, influenza A, and RSV infections in hospitalized children: a retrospective study
BackgroundThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A, and respiratory syncytial virus (RSV) infections have...
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Investigating rapid diagnostic testing in Kenya’s health system, 2018–2020: validating non-reporting in routine data using a health facility service assessment survey
BackgroundUnderstanding the availability of rapid diagnostic tests (RDTs) is essential for attaining universal health care and reducing health...
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Screening for PTSD and TBI in Veterans using Routine Clinical Laboratory Blood Tests
Post-traumatic stress disorder (PTSD) is a mental disorder diagnosed by clinical interviews, self-report measures and neuropsychological testing....
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Evidence Synthesis and Linkage for Modelling the Cost-Effectiveness of Diagnostic Tests: Preliminary Good Practice Recommendations
ObjectivesTo develop preliminary good practice recommendations for synthesising and linking evidence of treatment effectiveness when modelling the...
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The role of routine laboratory tests after unilateral total knee arthroplasty
BackgroundRecent studies suggest that routine laboratory tests are not required within 1 day after partial knee arthroplasty. In this study, we...
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Metagenomic next-generation sequencing as a diagnostic tool in the clinical routine of an infectious diseases department: a retrospective cohort study
BackgroundMetagenomic next-generation sequencing (mNGS) of circulating cell-free DNA from plasma is a hypothesis-independent broadband diagnostic...
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Extent of routine diagnostic cardiac work-up at certified German stroke units participating in the prospective MonDAFIS study
BackgroundAbout 25% of all ischaemic strokes are related to cardio-embolism, most often due to atrial fibrillation (AF). Little is known about the...
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Impact of molecular diagnostic tests on diagnostic and treatment delays in tuberculosis: a systematic review and meta-analysis
BackgroundCountries with high TB burden have expanded access to molecular diagnostic tests. However, their impact on reducing delays in TB diagnosis...
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Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas
Previous studies in patients with mature B-cell lymphomas (MBCL) have shown that pathogenic TP53 aberrations are associated with inferior...
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Accuracy of diagnostic tests in cardiac injury after blunt chest trauma: a systematic review and meta-analysis
IntroductionThe diagnosis of cardiac contusion, caused by blunt chest trauma, remains a challenge due to the non-specific symptoms it causes and the...
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Diagnostic tests for medullary thyroid carcinoma: an umbrella review
PurposeTo summarize the more robust evidence about the performance of tools useful for diagnosis of medullary thyroid carcinoma (MTC) such as...
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Inter-laboratory comparison of routine autoantibody detection methods for autoimmune neuropathies and myasthenia gravis
Serological tests are important to detect autoantibodies (autoAbs) in patients with autoimmune neuropathies (AN) and myasthenia gravis (MG) as they...
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Development and preliminary validation of a machine learning system for thyroid dysfunction diagnosis based on routine laboratory tests
BackgroundApproximately 2.4 million patients in Japan would benefit from treatment for thyroid disease, including Graves’ disease and Hashimoto’s...
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Diagnostic value of routine chest tube tip culture in surgery for noninfectious lung disease
BackgroundEvaluation of the diagnostic value of routine chest tube tip culture for detection of postoperative infection after surgery for...
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Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study
BackgroundRapid antigen diagnostic tests (Ag-RDTs) are the most widely used point-of-care tests for detecting SARS-CoV-2 infection. Since the...
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Implementation of a 7T Epilepsy Task Force consensus imaging protocol for routine presurgical epilepsy work-up: effect on diagnostic yield and lesion delineation
ObjectiveRecently, the 7 Tesla (7 T) Epilepsy Task Force published recommendations for 7 T magnetic resonance imaging (MRI) in patients with...
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Re-evaluating the necessity of routine laboratory tests after high tibial osteotomy surgery
BackgroundTo assess the utility of routine postoperative laboratory tests for patients undergoing high tibial osteotomy (HTO) surgery.
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Validation of a viable delirium detection test performed by nurses and physicians during routine patient care
BackgroundDelirium is a frequent mental impairment in geriatric patients hospitalized in acute care facilities. It carries a high risk of...
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Implementation of tuberculosis and cryptococcal meningitis rapid diagnostic tests amongst patients with advanced HIV at Kamuzu Central Hospital, Malawi, 2016–2017
BackgroundCryptococcal meningitis (CM) and tuberculosis (TB) remain leading causes of hospitalization and death amongst people living with HIV,...
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Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study
BackgroundSerological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect...
