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99mTc-labeled FAPI compounds for cancer and inflammation: from radiochemistry to the first clinical applications
BackgroundIn recent years, fibroblast activating protein (FAP), a biomarker overexpressed by cancer-associated fibroblasts, has emerged as one of the...
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Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China
IntroductionMetabolomic signatures of type 2 diabetes mellitus (T2DM) in Tibetan Chinese population, a group with high diabetes burden, remain...
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Evaluation of the wound healing effect of Nishamalaki, an Ayurvedic formulation comprising Curcuma longa and Phyllanthus emblica in aging rats
BackgroundThere are very few drugs available for healing wounds in the aged population, which is more prone to chronic cutaneous wounds that are...
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Dairy-originated digestion-resistant and bioactive peptides increase the risk of hypertension: Tehran Lipid and Glucose Study
Milk-protein-derived bioactive peptides (BPs) have been proposed as modulators of different regulatory processes involved in blood pressure...
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Dietary Strategies for Managing Short Bowel Syndrome
Purpose of reviewShort bowel syndrome (SBS) is an uncommon but important disease entity. Apart from parenteral support, dietary strategies are...
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Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can...
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Protective Effects of Anthocyanins Extracted from Vaccinium Uliginosum on 661W Cells Against Microwave-Induced Retinal Damage
ObjectiveTo study the protective effect of anthocyanins extracted from Vaccinium Uliginosum (VU) on retinal 661W cells against microwave radiation...
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Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats
BackgroundLipid profile and redox status play a role in brain (dys)functions. Cannabinoid and melatonergic systems operate in the brain and...
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Recent advances and applications of peptide–agent conjugates for targeting tumor cells
BackgroundCancer, being a complex disease, presents a major challenge for the scientific and medical communities. Peptide therapeutics have played a...
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Increased arginine, lysine, and methionine levels can improve the performance, gut integrity and immune status of turkeys but the effect is interactive and depends on challenge conditions
Arginine (Arg), lysine (Lys), and methionine (Met) can be used to support the health status of turkeys. The present study investigated selected...
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Modulatory effects of Ficus exasperata (Vahl) aqueous leaf extract against alcohol-induced testicular testosterone and total thiol pool perturbations in Wistar rats
An array of disorders caused by excessive alcohol consumption could be attributed to its reactive species (RS) generation power. Studies have...
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Zooming in and out of ferroptosis in human disease
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation. In the past decade, it has been implicated in...
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Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Sco** Review With Evidence Map**
IntroductionThere is currently no disease-modifying drug for osteoarthritis (OA), and some safety concerns have been identified about the leading...
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Mutation spectrum of COL1A1/COL1A2 screening by high-resolution melting analysis of Chinese patients with osteogenesis imperfecta
High-resolution melting (HRM) analysis has been shown to be a time-saving method for the screening of genetic variants. To increase the precision of...
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Realgar (α-As4S4) Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes (MDS). Aberrant DNA...
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Smart nanoparticles for cancer therapy
Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer...
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ACE inhibitory peptides in standard and fermented deer velvet: an in silico and in vitro investigation
BackgroundThe use of deer velvet antler (DVA) as a potent traditional medicine ingredient goes back for over 2000 years in Asia. Increasingly,...
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Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
A drug conjugate consists of a cytotoxic drug bound via a linker to a targeted ligand, allowing the targeted delivery of the drug to one or more...
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Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review
Human trichomoniasis, caused by the pathogenic parasitic protozoan Trichomonas vaginalis , is the most common non-viral sexually transmitted disease...
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Nanomedicine in cancer therapy
Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted...
