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The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective
AbstractThe nociceptive network, responsible for transmission of nociceptive signals that generate the pain experience, is not fully developed at...
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Descending serotonergic modulation from rostral ventromedial medulla to spinal trigeminal nucleus is involved in experimental occlusal interference-induced chronic orofacial hyperalgesia
BackgroundDental treatment associated with unadaptable occlusal alteration can cause chronic primary myofascial orofacial pain. The serotonin (5-HT)...
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Repeat mild traumatic brain injuries (RmTBI) modify nociception and disrupt orexinergic connectivity within the descending pain pathway
Repeat mild traumatic brain injuries (RmTBI) result in substantial burden to the public health system given their association with chronic...
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Wrist–ankle acupuncture attenuates cancer-induced bone pain by regulating descending pain-modulating system in a rat model
BackgroundCancer-induced bone pain (CIBP) presents a multiple-mechanism of chronic pain involving both inflammatory and neuropathic pain, and its...
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What goes up must come down: insights from studies on descending controls acting on spinal pain processing
Descending controls link higher processing of noxious signals to modulation of spinal cord responses to their noxious inputs. It has become possible...
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Medication overuse headache
Medication overuse headache (MOH) is a secondary headache disorder attributed to overuse of acute headache medications by a person with an underlying...
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Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
BackgroundMigraine is a disabling neurological disorder, characterized by recurrent headaches. During migraine attacks, individuals often experience...
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Descending Control Mechanisms and Chronic Pain
Purpose of ReviewThe goal of the review was to highlight recent advances in our understanding of descending pain-modulating systems and how these...
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Neurophysiological and behavioural correlates of ocrelizumab therapy on manual dexterity in patients with primary progressive multiple sclerosis
BackgroundHand dexterity impairment is a key feature of disability in people with primary progressive multiple sclerosis (PPMS). So far, ocrelizumab,...
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Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress
BackgroundChronic pain conditions impose significant burdens worldwide. Pharmacological treatments like opioids have limitations. Non-invasive...
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Pain mechanisms in complex regional pain syndrome: a systematic review and meta-analysis of quantitative sensory testing outcomes
BackgroundComplex regional pain syndrome (CRPS) is a chronic condition following inciting events such as fractures or surgeries with sensorimotor and...
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Normal parameters for diagnostic transcranial magnetic stimulation using a parabolic coil with biphasic pulse stimulation
BackgroundTMS is being used to aid in the diagnosis of central nervous system (CNS) illnesses. It is useful in planning rehabilitation programs and...
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Research Progress on the Experimental Model and Underlying Mechanistic Studies of Tension-Type Headaches
Purpose of ReviewTension-type headaches (TTH) significantly diminish patients’ quality of life and increase absenteeism, thereby imposing a...
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Benign food-borne type B botulism presenting as unilateral internal ophthalmoplegia: a case report
BackgroundFood-borne botulism is a rare neuromuscular junction disorder due to the effect of toxins released from Clostridium botulinum ingested by...
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Spinal cord stimulation modulates descending pain inhibition and temporal summation of pricking pain in patients with neuropathic pain
BackgroundSpinal cord stimulation (SCS) is an established treatment option for patients with refractory chronic pain conditions. While effects of SCS...
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Priming locomotor training with transspinal stimulation in people with spinal cord injury: study protocol of a randomized clinical trial
BackgroundThe seemingly simple tasks of standing and walking require continuous integration of complex spinal reflex circuits between descending...
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Managing Pain in Patients With Comorbid Alcohol Use Disorder and Chronic Pain
Purpose of ReviewThis narrative review describes the management of patients experiencing alcohol use disorder (AUD) and co-occurring chronic pain...
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The recent research progress in neurobiological characteristics and pain regulation of the cerebrospinal fluid-contacting nucleus
The ependymal epithelium forms the cerebrospinal fluid barrier, separating the brain and spinal cord from the cerebrospinal fluid. However, in...
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GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABAA-α4β1δ subunits in periaqueductal gray in female rats
BackgroundG-protein coupled estrogen receptor 30 (GPR30) was proved the specific estrogen receptor relating to mechanical hyperalgesia. Studies have...
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A mechanism-based proof of concept study on the effects of duloxetine in patients with painful knee osteoarthritis
BackgroundThe global burden of osteoarthritis (OA) is steadily increasing due to demographic and lifestyle changes. The nervous system can undergo...
