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Evaluation of deprescription by general practitioners in elderly people with different levels of dependence: cross-sectional study
BackgroundPolypharmacy is easily achieved in elderly patients with multimorbidity and it is associated with a higher risk of potentially...
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Intravenous ketamine for benzodiazepine deprescription and withdrawal management in treatment-resistant depression: a preliminary report
We present the first evidence that sub-anesthetic ketamine infusions for treatment resistant depression (TRD) may facilitate deprescription of...
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Impact of Glucagon-Like Peptide 1 Agonist Deprescription in Type 2 Diabetes in a Real-World Setting: A Propensity Score Matched Cohort Study
IntroductionGlucagon-like peptide 1 receptor agonists (GLP-1) elicit substantial reductions in glycemia and body weight in people with type 2...
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Evidence for deprescription in primary care through an umbrella review
BackgroundThere is a high prevalence of potentially inappropriate prescriptions in primary care. This is associated with more frequent adverse...
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The PROMISING Project: A Pilot Study to Improve Geriatric Care Through a Pharmacist-Led Psychotropic Stewardship Program
Background and objectivePsychotropic medications are frequently prescribed during acute care, even in older patients. They represent a risk for...
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What Makes Deprescription of Psychotropic Drugs in Nursing Home Residents with Dementia so Challenging? A Qualitative Systematic Review of Barriers and Facilitators
BackgroundBehavioral and psychological symptoms of dementia are frequently experienced in the nursing home setting and place a substantial burden on...
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Deprescribing clonazepam in primary care older patients: a feasibility study
Background Inappropriate use of clonazepam by older adults is associated with cognitive impairment, delirium, and falls. Strategies to optimize its...
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Impact of Pharmaceutical Interventions with STOPP/START and PIM-Check in Older Hospitalized Patients: A Randomized Controlled Trial
IntroductionPharmaceutical interventions can reduce negative outcomes related to potentially inappropriate prescriptions (PIPs).
Objective ...
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Polypharmacy in Older Heart Failure Patients: a Multidisciplinary Approach
Purpose of ReviewWe provide a review of considerations when applying principles of optimal pharmacotherapy to older adults with heart failure (HF),...
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Development of a multidisciplinary medication management program in nursing homes: protocol for a randomized controlled trial
BackgroundPolypharmacy and the use of potentially inappropriate medications are common among nursing home residents and are associated with negative...
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Potentially inappropriate prescriptions and therapeutic complexity in older HIV patients with comorbidities
Background : The prolonged current survival of human immunodeficiency virus (HIV) patients exposes them to new problems arising from the comorbidities...
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Drug landscape in patients receiving general outpatient palliative care in Germany: results from a retrospective analysis of 10,464 patients
BackgroundAccording to § 27 and § 87 1b of the German Social Code, Book V, general outpatient palliative care (GOPC) aims to promote, maintain, and...
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Chronic benzodiazepine usage among older people: prevalence, indications, and treatment modifications in patients admitted to an acute geriatric unit
AimTo investigate the prevalence and indications of benzodiazepines (BZD) usage among patients admitted to an acute geriatric unit and assess changes...
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Improving patient experience for people prescribed medicines with a risk of dependence or withdrawal: co-designed solutions using experience based co-design
BackgroundSignificant concerns have been raised regarding how medications with a risk of dependence or withdrawal are managed and how care is...
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Appropriate medication use in Dutch terminal care: study protocol of a multicentre stepped-wedge cluster randomized controlled trial (the AMUSE study)
BackgroundPolypharmacy is common among patients with a limited life expectancy, even shortly before death. This is partly inevitable, because these...
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Polypharmacy and sustainable developmental goals: linking evidence-based medicine, patient engagement, and shared decision-making
Sustainable Development Goals (SDGs) are an urgent call for action adopted by the United Nations to improve health and education, reduce inequality,...
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Tackling potentially inappropriate prescriptions in older adults: development of deprescribing criteria by consensus from experts in Colombia, Argentina, and Spain
BackgroundPotentially inappropriate medication use is prevalent among older adults in primary care, leading to increased morbidity, adverse drug...
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A multi- and mixed-method adaptation study of a patient-centered perioperative mental health intervention bundle
BackgroundAnxiety and depression are common among older adults and can intensify during perioperative periods, but few mental health interventions...
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Medication changes and potentially inappropriate prescribing in older patients with significant polypharmacy
BackgroundNumber of medicines and medicines appropriateness are often used as outcome measures to evaluate the effectiveness of deprescribing...
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Proactive Polypharmacy Management Using Large Language Models: Opportunities to Enhance Geriatric Care
Polypharmacy remains an important challenge for patients with extensive medical complexity. Given the primary care shortage and the increasing aging...