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Association of rare variants in genes of immune regulation with pediatric autoimmune CNS diseases
BackgroundThere is a gap in the literature regarding genetic underpinnings of pediatric autoimmune CNS diseases. This study explored rare gene...
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Neuromyelitis Optica: Pathogenesis Overlap with Other Autoimmune Diseases
Purpose of ReviewNeuromyelitis optica (NMO) is an auto-immune disease essentially depicted by optic neuritis and transverse myelitis. Per se, NMO was...
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Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
BackgroundIn addition to decreasing the level of cholesterol, proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has pleiotropic effects,...
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Demyelinating plaque-associated uveitis
PurposeTo report the clinical and fluorescein angiographic (FA) features of demyelinating plaque-associated uveitis (DPU), a subset of uveitis in...
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Immunopathogenesis of viral infections in neurological autoimmune disease
Autoimmune diseases develop due to self-tolerance failure in recognizing self and non-self-antigens. Several factors play a role in inducing...
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Nervous regulation: beta-2-adrenergic signaling in immune homeostasis, cancer immunotherapy, and autoimmune diseases
Beta-2-adrenergic receptor ( β 2 -AR) mediates neural signaling from the sympathetic nervous system (SNS) to the immune system to modulate immunogenic...
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Efficacy and safety of gut microbiota-based therapies in autoimmune and rheumatic diseases: a systematic review and meta-analysis of 80 randomized controlled trials
BackgroundPrevious randomized controlled trials (RCTs) suggested that gut microbiota-based therapies may be effective in treating autoimmune...
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Growing Spectrum of Autoimmune Nodopathies
Purpose of ReviewRecognition of node of Ranvier as the site of injury in inflammatory neuropathies contributed to discovery of antibodies against the...
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Origins and immunopathogenesis of autoimmune central nervous system disorders
The field of autoimmune neurology is rapidly evolving, and recent discoveries have advanced our understanding of disease aetiologies. In this...
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BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair
In multiple sclerosis (MS), persisting disability can occur independent of relapse activity or development of new central nervous system (CNS)...
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Immune Checkpoint Inhibitors in Patients with Pre-existing Neurologic Autoimmune Disorders
Purpose of ReviewThe use of immune checkpoint inhibitors (ICIs) for oncologic indications is associated with immune-related adverse events (irAEs)....
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Coronavirus disease 2019 (COVID-19) in pediatric patients with autoimmune disorders
Coronavirus disease 2019 (COVID-19) infection in pediatric patients with autoimmune disorders is an area of particular concern since autoimmune...
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Astrocytes in human central nervous system diseases: a frontier for new therapies
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS)....
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Progressive demyelinating polyneuropathy after hematopoietic cell transplantation in metachromatic leukodystrophy: a case series
Metachromatic leukodystrophy (MLD) is a neuro-metabolic disorder due to arylsulfatase A deficiency, causing demyelination of the central and...
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Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
With the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment....
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High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study
BackgroundWe proposed to investigate high-dose pharmaceutical-grade biotin in a population of demyelinating neuropathies of different aetiologies, as...
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Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy
Previous studies have reported an association between anti-tumor necrosis factor alpha (anti-TNFα) treatment and central nervous system (CNS) events....
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Identifying high-risk neurological phenotypes in adult-onset classic monogenic autoinflammatory diseases: when should neurologists consider testing?
BackgroundMonogenic autoinflammatory disorders result in a diverse range of neurological symptoms in adults, often leading to diagnostic delays....
