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An overview of DNA degradation and its implications in forensic caseworks
BackgroundDNA (deoxy-ribonucleic acid) is a fundamental molecule housing genetic information crucial for forensic casework. However, its integrity is...
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UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance
Prostate cancer (PCa) is primarily driven by aberrant Androgen Receptor (AR) signaling. Although there has been substantial advancement in...
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DNA degradation of bloodstains on cotton fabric caused by different washing procedures
DNA degradation in biological material needs to be better understood. Bloodstains on washed clothing are disturbed by washing procedures, sometimes...
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Effect of temporary freezing on postmortem protein degradation patterns
BackgroundA precise determination of time since death plays a major role in forensic routine. Currently available techniques for estimating the...
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CRL2KLHDC3 and CRL1Fbxw7 cooperatively mediate c-Myc degradation
c-Myc is a proto-oncoprotein that regulates various cellular processes and whose abnormal expression leads to tumorigenesis. c-Myc protein stability...
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Protein degradation: expanding the toolbox to restrain cancer drug resistance
Despite significant progress in clinical management, drug resistance remains a major obstacle. Recent research based on protein degradation to...
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The biological effects and thermal degradation of NPB-22, a synthetic cannabinoid
PurposeNPB-22 (quinolin-8-yl 1-pentyl-1 H -indazole-3-carboxylate), Adamantyl-THPINACA ( N -(1-adamantantyl)-1-[(tetrahydro-2 H -pyran-4-yl)methyl]-1 H -inda...
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Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development
The 5′-HOXD genes are important for chondrogenesis in vertebrates, but their roles in osteoarthritis (OA) are still ambiguous. In our study, 5′-HOXD ...
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FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation
ObjectiveFerritin heavy chain 1 (FTH1) is an important subunit of ferro-storing proteins and is indispensable for iron metabolism. Though it has been...
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Dentin Degradation: From Tissue Breakdown to Possibilities for Therapeutic Intervention
Purpose of the ReviewPresently, dental materials science is driven by the search for new and improved materials that can trigger specific reactions...
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PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both histones and non-histones asymmetrically. Increasing evidence...
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Degradation Adaption Local-to-Global Transformer for Low-Dose CT Image Denoising
Computer tomography (CT) has played an essential role in the field of medical diagnosis. Considering the potential risk of exposing patients to X-ray...
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Effect of 5% albumin on endothelial glycocalyx degradation during off-pump coronary artery bypass
PurposeThe integrity of the endothelial glycocalyx (EG), a critical player in vascular homeostasis, reportedly influences the outcomes of critically...
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FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation
FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1, CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the...
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UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation
Mutations in E3 ubiquitin ligase UBE3B have been linked to Kaufman Oculocerebrofacial Syndrome (KOS). Accumulating evidence indicates that UBE3B may...
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TRIM26 facilitates PRV infection through NDP52-mediated autophagic degradation of MAVS
Pseudorabies virus (PRV) has evolved multiple strategies to evade host antiviral responses to benefit virus replication and establish persistent...
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D-mannose promotes the degradation of IDH2 through upregulation of RNF185 and suppresses breast cancer
BackgroundD-mannose, an epimer of glucose, which is abundant in some fruits, such as cranberry, has been previously reported to inhibit urinary tract...
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E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression
Glioblastoma (GBM) is the most common malignant glioma, with a high recurrence rate and a poor prognosis. However, the molecular mechanism behind the...
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MARCH5 promotes hepatocellular carcinoma progression by inducing p53 ubiquitination degradation
BackgroundHuman MARCH5 is a mitochondria-localized E3 ubiquitin-protein ligase that is essential for the regulation of mitochondrial dynamics. A...
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Exosomal circRHCG promotes breast cancer metastasis via facilitating M2 polarization through TFEB ubiquitination and degradation
Triple-negative breast cancer (TNBC) is a highly aggressive cancer with distant metastasis. Accumulated evidence has demonstrated that exosomes are...
