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De novo versus recurrent metastatic breast cancer affects the extent of brain metastases
PurposeWe aimed to identify factors associated with the extent of brain metastases in patients with breast cancer to help distinguish brain...
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Surgery of the primary tumor in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium
PurposeWe aimed to assess the impact of surgery of primary tumor in overall survival (OS) of women with de novo metastatic breast cancer.
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Time trends in real-world treatment patterns and survival in patients diagnosed with de novo HER2+ metastatic breast cancer: an analysis of the SONABRE registry
PurposeThe aim was to determine whether the real-world first-line progression-free survival (PFS) of patients diagnosed with de novo human epidermal...
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Comparison between de novo and metachronous metastatic breast cancer: the presence of a primary tumour is not the only difference—a Dutch population-based study from 2008 to 2018
PurposeThe aim of this study was to compare characteristics and survival of patients with de novo and metachronous metastatic breast cancer.
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Clinical subtype, treatment response, and survival in De Novo and recurrent metastatic breast cancer
PurposeThis study evaluated whether patients with de novo metastatic breast cancer (MBC) have superior outcomes compared to those with recurrent MBC...
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Surgical Treatment of de novo Metastatic Breast Cancer
Purpose of reviewDe novo metastatic breast cancer (dnMBC) accounts for approximately 6% of all new breast cancers each year. While the survival...
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Palliative care utilization and racial and ethnic disparities among women with de novo metastatic breast cancer in the United States
PurposeThe potential disparities in palliative care delivery for underrepresented minorities with breast cancer are not well known. We sought to...
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Primary-Site Local Therapy for Patients with De Novo Metastatic Breast Cancer: An Educational Review
BackgroundUntil 2001, the paradigm guiding the management of women with de novo metastatic breast cancer (dnMBC) stipulated that primary-site...
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Predictors of long-term durable response in de novo HER2-positive metastatic breast cancer and the real-world treatment experience at two institutions
PurposeHER2-directed therapies enable some patients with de novo HER2+ metastatic breast cancer (MBC) to achieve long-term, durable responses (DR)....
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Clinico–pathologic factors and survival of patients with breast cancer diagnosed with de novo brain metastasis: a national cancer database analysis
PurposePatients with Breast Cancer (BC) with Brain Metastasis (BCBM) have poor survival outcomes. We aimed to explore the clinico–pathologic and...
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Trastuzumab therapy duration in HER2-positive de novo metastatic breast cancer: 1999–2018
PurposeThe optimal duration of first-line trastuzumab (T) treatment for de novo stage IV HER2-positive metastatic breast cancer (MBC) patients after...
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Impact of socioeconomic status and rurality on cancer-specific survival among women with de novo metastatic breast cancer by race/ethnicity
PurposeThere are approximately 150,000 women living with metastatic breast cancer (mBC) in the United States. Disparities in de novo mBC incidence...
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Should We Completely Exclude Locoregional Therapy for the Primary Tumor from Our Clinical Practice in De Novo Metastatic Breast Cancer?
Locoregional therapy (LRT) for the primary site of breast cancer (BC) is one of the most debated topics in de novo metastatic disease. We have four...
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Efficacy of Lapatinib Plus Capecitabine After TDM-1 in HER2-Positive Metastatic Breast Cancer Patients
Different targeted therapy options exist for treating HER2-positive metastatic breast cancer patients. This study evaluated the efficacy and...
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Modified Radical Mastectomy in De Novo Stage IV Inflammatory Breast Cancer
BackgroundThere are few studies on surgical management in patients with de novo metastatic inflammatory breast cancer (IBC). The objective of this...
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Locoregional tumor burden and risk of mortality in metastatic breast cancer
The role of lymph node involvement and tumor size in metastatic disease including breast cancer is unclear. Here, nodal metastasis and T stage on the...
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Racialized economic segregation and inequities in treatment initiation and survival among patients with metastatic breast cancer
PurposeRacialized economic segregation, a form of structural racism, may drive persistent inequities among patients with breast cancer. We examined...
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Survival, treatment patterns, and costs of HER2+ metastatic breast cancer patients in Ontario between 2005 to 2020
BackgroundTo enable the integration of novel therapies, it is critical to understand current long-term outcomes in HER2-positive metastatic breast...
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Metastatic Triple-Negative Breast Cancer
Purpose of ReviewTriple-negative breast cancer (TNBC) is a heterogeneous disease group with a known aggressive phenotype and poor prognosis. To date,...
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Survival among patients with untreated metastatic breast cancer: “What if I do nothing?”
PurposeWe sought to assess survival outcomes of patients with de novo metastatic breast cancer (dnMBC) who did not receive treatment irrespective of...
