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Use of days alive without life support and similar count outcomes in randomised clinical trials – an overview and comparison of methodological choices and analysis methods
BackgroundDays alive without life support (DAWOLS) and similar outcomes that seek to summarise mortality and non-mortality experiences are...
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Postoperative high-sensitivity troponin T predicts 1-year mortality and days alive and out of hospital after orthotopic heart transplantation
BackgroundOrthotopic heart transplantation (HTX) is the gold standard to treat end-stage heart failure. Numerous risk stratification tools have been...
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Days spent on non-invasive ventilation support: can it determine when to initiate VV- ECMO? Observational study in a cohort of Covid-19 patients
BackgroundThe study evaluates the impact of the time between commencing non-invasive ventilation (NIV) support and initiation of venovenous...
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Patshitinikutau Natukunisha Tshishennuat Uitshuau (a place for Elders to spend their last days in life): a qualitative study about Innu perspectives on end-of-life care
BackgroundIndigenous palliative persons and their families often have different values, spiritual traditions, and practices from Western culture and...
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Complication accrual impacts pediatric extracorporeal life support mortality
IntroductionThis study tested the hypothesis that complication accrual during pediatric extracorporeal life support (ECLS) increases mortality...
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Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis
PurposeOptimal oxygenation targets for patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are not clearly defined due...
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Favorable, arduous or fatal postoperative pathway within 90 days of lung transplantation
IntroductionThe maximum gain in quality of life after lung transplantation (LT) is expected between six months and one year after LT, as the...
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Between Life and Death: How do Muslim Terminal Patients in Pakistan cope with Hepatitis C utilizing their Beliefs and Social Support?
Life-threatening events including terminal illness intensify the search for meaning and incite individuals to get closer to religion. Terminal...
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“Just fighting for my life to stay alive”: a qualitative investigation of barriers and facilitators to community re-entry among people with opioid use disorder and incarceration histories
BackgroundDuring the period of community re-entry immediately following release from jail or prison, individuals with opioid use disorder (OUD) face...
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Applying the Hybrid Concept as a Bridge to Transplantation in Infants Without Hypoplastic Left Heart Syndrome
Therapies to support small infants in decompensated heart failure that are failing medical management are limited. We have used the hybrid approach,...
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Health-Related Quality of Life in Pediatric Cardiac Patients After Extracorporeal Life Support
Extracorporeal Life Support (ECLS) is often considered successful if the child leaves intensive care alive. For the child and family, a major concern...
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Potential for recovery after extremely prolonged VV-ECMO support in well-selected severe COVID-19 patients: a retrospective cohort study
BackgroundVenoVenous ExtraCorporeal Membrane Oxygenation (VV-ECMO) has been widely used as supportive therapy for severe respiratory failure related...
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Impact of corticosteroids on the duration of ventilatory support during severe acute exacerbations of chronic obstructive pulmonary disease in patients in the intensive care unit: a study protocol for a multicentre, randomized, placebo-controlled, double-blind trial
BackgroundPatients who are admitted to the intensive care unit (ICU) for severe acute exacerbations of chronic obstructive pulmonary disease (COPD)...
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Reduced anticoagulation targets in extracorporeal life support (RATE): study protocol for a randomized controlled trial
BackgroundAlthough life-saving in selected patients, ECMO treatment still has high mortality which for a large part is due to treatment-related...
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Healthcare Utilization and Mortality After Hospice Live Discharge Among Medicare Patients With and Without Alzheimer’s Disease and Related Dementias
BackgroundLittle is known about post-discharge outcomes among patients who were discharged alive from hospice.
ObjectiveTo compare healthcare...
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Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial
BackgroundAdministration of sedative and opioid medications to patients receiving mechanical ventilatory support in the intensive care unit is a...
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Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support
BackgroundThere is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported...
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Multiple-site decontamination to prevent acquired infection in patients with veno-venous ECMO support
BackgroundAcute distress respiratory syndrome (ARDS) patients with veno-venous extra corporeal membrane oxygenation (ECMO) support are particularly...
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Quality of life and secondary outcomes for open versus robot-assisted radical cystectomy: a double-blinded, randomised feasibility trial
PurposeThis study aims to examine quality of life (QoL) before and after radical cystectomy (RC) and compare robot-assisted laparoscopy with...
