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1. Epigenetic silencing of LDHB promotes hepatocellular carcinoma by remodeling the tumor microenvironment

   Lactate dehydrogenase B (LDHB) reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate and expressed in various...

   Peng Zhang, Yi Wan, ... Chengsheng Zhang in Cancer Immunology, Immunotherapy

   Article Open access 13 May 2024
   

2. Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip

   Background

   This study aimed to validate alterations in the gene expression of DNA methylation-related enzymes and global methylation in the peripheral...

   Yuya Kawarai, Junichi Nakamura, ... Seiji Ohtori in Journal of Orthopaedic Surgery and Research

   Article Open access 16 June 2024
   

3. Distinct global DNA methylation and NF-κB expression profile of preimplantation biopsies from ideal and non-ideal kidneys

   Background

   Epigenetic mechanisms may affect the ideal and non-ideal kidneys selected for transplantation and their inflammatory gene expression...

   Naiane do Nascimento Gonçalves, Heloisa Cristina Caldas, ... Mario Abbud-Filho in Journal of Nephrology

   Article 08 September 2022
   

4. Catechin-Induced changes in PODXL, DNMTs, and miRNA expression in Nalm6 cells: an integrated in silico and in vitro approach

   Background

   This study explored the impact of predicted miRNAs on DNA methyltransferases (DNMTs) and the PODXL gene in Nalm6 cells, revealing the...

   Ali Afgar, Alireza Keyhani, ... Reza Vahidi in BMC Complementary Medicine and Therapies

   Article Open access 15 June 2024
   

5. Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells

   Purpose

   We have previously shown that TRDMT1 methyltransferase is a regulator of chemotherapy-associated responses in glioblastoma cells. Despite the...

   Tomasz Zabek, Tomasz Szmatola, ... Maciej Wnuk in Journal of Neuro-Oncology

   Article Open access 11 May 2023
   

6. Maternal exercise upregulates the DNA methylation of Agtr1a to enhance vascular function in offspring of hypertensive rats

   The angiotensin II signaling system regulates vascular dysfunction and is involved in the programming of hypertension. Maternal exercise has been...

   Meiling Shan, Shanshan Li, ... Lijun Shi in Hypertension Research

   Article 20 December 2022
   

7. Hypermethylation of Klotho and Peroxisome Proliferator-Activated Receptor γ Concomitant with Overexpression of DNA Methyltransferase 1 in Adenomyosis

   Cellular senescence is known to be involved in tissue repair, but its role in adenomyosis remains unclear. This study was tasked to evaluate the...

   Jiao Fan, **shi Liu, Sun-Wei Guo in Reproductive Sciences

   Article 30 May 2024
   

8. Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylation

   Purpose

   DNA methylation is one of the epigenetic mechanisms that plays critical roles in preimplantation embryo development executed by DNA...

   Fatma Uysal, Ozgur Cinar, Alp Can in Journal of Assisted Reproduction and Genetics

   Article 17 September 2021
   

9. Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors

   Significant reprogramming of epigenome is widely described during pathogenesis of breast cancer. Transformation of normal cell to hyperplastic cell...

   Mangala Hegde, Manjunath B. Joshi in Journal of Cancer Research and Clinical Oncology

   Article Open access 18 February 2021
   

10. The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis

    PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression. Inhibition of...

    Yenan Fu, ** Zhang, ... Hongquan Zhang in Signal Transduction and Targeted Therapy

    Article Open access 21 March 2022
    

11. 5-aza-2′-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas

    Background

    Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related...

    María Cristina Carbajo-García, Ana Corachán, ... Hortensia Ferrero in Reproductive Biology and Endocrinology

    Article Open access 08 July 2021
    

12. Molecular predictors for decitabine efficacy in meningiomas – a pilot study

    Purpose

    Effective chemotherapeutical agents for the treatment of meningiomas are still lacking. Previous in-vitro analyses revealed efficacy of...

    Dorothee C. Spille, Christian Thomas, ... Benjamin Brokinkel in Journal of Neuro-Oncology

    Article 21 July 2023
    

13. A phthalimidoalkanamide derived novel DNMT inhibitor enhanced radiosensitivity of A549 cells by inhibition of homologous recombination of DNA damage

    Purpose To elucidate the radiosensitizing effect and underlying mechanism of a new kind of DNA methyltransferase (DNMT) inhibitor with biological...

    Hyun-Cheol Kang, Eui Kyu Chie, ... EunSook Ma in Investigational New Drugs

    Article 22 February 2019
    

14. Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1

    Epigenetic factors are well-established players in memory formation. Specifically, DNA methylation is necessary for the formation of long-term memory...

    Janina Kupke, Julien Klimmt, ... Ana M. M. Oliveira in Neuropsychopharmacology

    Article Open access 18 March 2024
    

15. STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation

    Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutations. However, the functional effects of STAT3 ...

    Daehong Kim, Giljun Park, ... Satu Mustjoki in Leukemia

    Article Open access 01 June 2021
    

16. Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis

    Osteoporosis (OP) is a common skeletal disease involving low bone mineral density (BMD) that often leads to fragility fracture, and its development...

    **ngren Chen, **aobo Zhu, ... Wangsen Cao in Bone Research

    Article Open access 26 February 2021
    

17. Dnmt3b ablation affects fracture repair process by regulating apoptosis

    Purpose

    Previous studies have shown that DNA methyltransferase 3b (Dnmt3b) is the only Dnmt responsive to fracture repair and Dnmt3b ablation in...

    Xu Wang, Qinwen Ge, ... Taotao Xu in BMC Musculoskeletal Disorders

    Article Open access 27 February 2024
    

18. Enhancer of Zeste Homolog 2 (EZH2) in Malignant Progression of Gallbladder Carcinoma

    Purpose

    Data related to the role of epigenetic modifications in gallbladder carcinoma (GBC) is limited. We intended to assess the role of crucial...

    Gayatri Behera, Suvradeep Mitra, ... Suvendu Purkait in Journal of Gastrointestinal Cancer

    Article 14 October 2020
    

19. Hypomethylating Agents in Lymphoma

    Epigenetic mutations are frequent and pathogenic in select subtypes of lymphoma, and agents modulating DNA and histone methylation—such as inhibitors...

    Jacob C. Cogan, Yuxuan Liu, Jennifer E. Amengual in Current Treatment Options in Oncology

    Article 29 June 2020
    

20. Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

    DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of epigenetic modulating drugs is a promising anti-cancer...

    Mathieu Vernier, Shawn McGuirk, ... Vincent Giguère in Oncogene

    Article Open access 27 August 2020