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Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis
Metastasis is the leading cause of cancer-related deaths. Transforming growth factor beta (TGF-β) signaling drives metastasis and is strongly...
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ER stress–related protein, CHOP, may serve as a biomarker of mechanical asphyxia: a primary study
The precise authentication of death from mechanical asphyxia (DMA) has been a complex problem in forensic medicine. Besides the traditional methods...
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N,N-Dimethylformamide Delays LPS-Induced Preterm Birth in a Murine Model by Suppressing the Inflammatory Response
Preterm birth accounts for the majority of perinatal mortality worldwide, and there remains no FDA-approved drug to prevent it. Recently, we...
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Pharmacokinetics and Pharmacodynamics of Patisiran in Patients with hATTR Amyloidosis and with Polyneuropathy After Liver Transplantation
Background and ObjectiveVariants of the transthyretin ( TTR ) gene cause hereditary transthyretin-mediated (hATTR) amyloidosis, or ATTRv amyloidosis...
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ALOX5AP suppresses osteosarcoma progression via Wnt/β-catenin/EMT pathway and associates with clinical prognosis and immune infiltration
Osteosarcoma (OS) is one of the most common malignant neoplasms in children and adolescents. Immune infiltration into the microenvironment of the...
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Securing the surgical field for mobilization of right-sided colon cancer using the duodenum-first multidirectional approach in laparoscopic surgery
BackgroundThe aim of this study was to compare the short-term outcomes of the duodenum-first multidirectional approach (DMA) in laparoscopic right...
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Compliance with Dietary Recommendations and Sociodemographic Factors in a Cross-Sectional Study of Natives and Immigrants in Spain
To analyze compliance with dietary recommendations (DR) based on the Mediterranean Diet among natives and immigrants in Spain. A cross-sectional...
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A study on the current state and equity level of social participation ability among older adults in Henan Province, China
BackgroundThe social participation ability among older adults (SPAOA) plays an important role in enhancing their quality of life and utilization of...
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The impact of the diabetes management incentive on diabetes-related services: evidence from Ontario, Canada
Financial incentives have been introduced in several countries to improve diabetes management. In Ontario, the most populous province in Canada, a...
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Demographic predictors of urinary arsenic in a low-income predominantly Hispanic pregnancy cohort in Los Angeles
BackgroundArsenic (As) is a contaminant of top public health concern, due to its range of detrimental health effects. Arsenic exposure has not been...
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The situation and influencing factors of outpatient satisfaction in large hospitals: Evidence from Henan province, China
BackgroundThe level of outpatient satisfaction plays a significant role in improving the quality and utilization of healthcare services. Patient...
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Which interventions for alcohol use should be included in a universal healthcare benefit package? An umbrella review of targeted interventions to address harmful drinking and dependence
BackgroundThis study aimed to identify targeted interventions for the prevention and treatment of harmful alcohol use. Umbrella review methodology...
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Cutaneous vascularization of the proximal two-thirds of the dorsal aspect of the hand: descriptive anatomical study of a perforating arterial arch
PurposeSeveral reports have suggested that transverse arches between the radial and ulnar sides of dorsal hand skin supply the proximal part of the...
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The foul play of two dietary metabolites trimethylamine (TMA) and trimethylamine N-oxide (TMAO) on human health and the role of microbes in mitigating their effects
PurposeThis review summarizes the effects of trimethylamine N-oxide (TMAO) on human health and the role of microbes in mitigating this problem....
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Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy
Joint kinematic instability, arising from congenital or acquired musculoskeletal pathoanatomy or from imbalances in anabolism and catabolism induced...
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Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis
ObjectiveImmune checkpoints have emerged as promising therapeutic targets for autoimmune diseases. However, the specific roles of immune checkpoints...
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Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide
BackgroundArsenic trioxide [ATO, inorganic arsenite (iAs III ) in solution] plays an important role in the treatment of acute promyelocytic leukemia...
