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Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities
Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies, successfully used for decades, continue to transform the lives of...
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Hybrid chitosan gold nanoparticles for photothermal therapy and enhanced cytotoxic action of 6-mercaptopurine on breast cancer cell line
BackgroundOne of the most popular anti-inflammatory and anti-leukemic medications is 6-mercaptopurine, along with its riboside derivatives. Because...
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Targeting cytotoxic lymphocyte antigen 4 (CTLA-4) in breast cancer
Breast cancer (BC) has a high mortality rate and is one of the most common malignancies in the world. Initially, BC was considered non-immunogenic,...
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Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy and improved survival in a growing number of cancers. Despite their success, ICIs are...
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Examining the effect of activated cytotoxic (CD8+) T-cell exosomes to the lung cancer
Lung cancer continues to be a major health problem worldwide owing to its incidence, and causes physical, psychological, social, and economic...
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Rapid tumor progression complicated with liver abscess in a patient with gastric cancer receiving nivolumab therapy
Immune checkpoint inhibitors have been approved for treating various cancer types. However, several studies reported rapid tumor progression, a...
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Cytotoxic chemotherapy is associated with decreased bone mineral density in postmenopausal women with early and locally advanced breast cancer
PurposeThe burden and mechanisms of endocrine therapy-related bone loss have been studied in detail. However, there is limited data regarding...
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Myeloid-derived suppressor cells in cancer and cancer therapy
Anticancer agents continue to dominate the list of newly approved drugs, approximately half of which are immunotherapies. This trend illustrates the...
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Immune checkpoint inhibitor therapy in neoadjuvant and adjuvant treatment for cancer: A paradigm shift in the treatment of resectable gastrointestinal cancer 3)A paradigm shift in the treatment of colorectal cancer
Immune checkpoint inhibitors, such as anti-programmed cell death-1, programmed cell death ligand-1, and cytotoxic T-lymphocyte antigen-4 monoclonal...
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High neutrophil-to-lymphocyte ratio is associated with cancer therapy-related cardiovascular toxicity in high-risk cancer patients under immune checkpoint inhibitor therapy
BackgroundCancer therapy-related cardiovascular toxicity (CTR-CVT) from immune checkpoint inhibitor (ICI) therapy is still incompletely...
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A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure
Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition...
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Drug repurposing for cancer therapy
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical,...
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Treatment of node-positive endometrial cancer: chemotherapy, radiation, immunotherapy, and targeted therapy
The standard of treatment for node-positive endometrial cancer (FIGO Stage IIIC) in North America has been systemic therapy with or without...
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Negative impact on bone homeostasis in postmenopausal women with non-metastatic breast cancer during cytotoxic chemotherapy
IntroductionThe burden and mechanisms of endocrine therapy-related bone loss are well known, while there are limited data on chemotherapy-induced...
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Cancer stem cells: advances in knowledge and implications for cancer therapy
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to...
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Hair loss during and after breast cancer therapy
For patients diagnosed with breast cancer, alopecia can be a distressing side effect of treatment. Major surgeries, cytotoxic chemotherapy, and...
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Evaluation of the cytotoxic activities of the essential oil from Pistacia atlantica Desf. oleoresin on human gastric cancer cell lines
Numerous herbal products have been the subject of research regarding their potential role in cancer prevention or adjuvant therapy. Pistacia atlantica ...
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Estrogen receptor positive breast cancer: contemporary nuances to sequencing therapy
The treatment landscape of hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer has evolved...
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In vitro cytotoxic effect of stigmasterol derivatives against breast cancer cells
BackgroundStigmasterol is an unsaturated phytosterol that belong to the class of tetracyclic steroids abundant in Rhoicissus tridentata ....
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Evaluation of the effects of photodynamic therapy consisted of the blue laser and zinc oxide QDs on MDA-MB-231 cancer cells by inhibiting cancer markers and inducing apoptosis
The increasing number of cancer patients has cast attention on develo** new anti-cancer modalities. Photodynamic therapy is a safe anti-cancer...
